Drug treatment methods for teratoma

The female body has to go through normal physiological processes such as menstruation, pregnancy, and childbirth. Therefore, if you do not take good care of your body and balance it, you will easily develop various physical diseases and gynecological diseases. For example, gynecological inflammation, ovarian cysts, vaginitis and other diseases. Ovarian teratoma is a common ovarian germ cell tumor. Especially for women of childbearing age, this disease should be paid close attention to. Ovarian teratoma is divided into benign and malignant. Malignant teratoma can even be life-threatening.

Drug treatment for teratoma

1. Chemotherapy

For mixed teratomas, only chlorambucil (CI, B) can be used, at 0.1 mg/(kgd) orally for 12 weeks. For malignant teratomas, chemotherapy should be given after surgical resection. Commonly used chemotherapy regimens are as follows: POMB/ACE alternating therapy: POMB regimen: vincristine (VCR) 1.5 mg/m2, intravenous injection, day 1; methotrexate (MTX) 100 mg/m2. Intravenous drip (lasting 12 hours), day 1; calcium folinate (CF) rescue, 15 mg, once/12 hours, days 2 and 3; bleomycin (BLM) 10-20 mg/m2, intravenous injection (lasting 24 hours), day 3; cisplatin (DDP) 60 mg/m2, intravenous drip, day 4; 2 weeks as a course of treatment. ACE regimen: etoposide (VP16) 100mg/m2, intravenous injection, days 1 to 5; actinomycin D (ACD) 0.45mg/m2, intravenous injection, days 3 to 5; cyclophosphamide (CTX) 500mg/m2, intravenous injection, day 5; 2 weeks as a course of treatment. After POMB2 courses, PONfB and ACE are used alternately. The total course of treatment is 1 year. DVB regimen: DDP 20mg/m2, intravenous injection, days 1 to 5; vinblastine (VLB) 0.15-0.2mg/kg, intravenous injection, days 1 and 2; BLM 10-20mg/m2, intravenous injection, days 1, 8, and 15. Every 3 weeks is a course of treatment. After 4 courses of treatment, surgery was performed, and CA chemotherapy was given after surgery: CA chemotherapy: CTX 500 mg/m2, intravenous injection, day 1; doxorubicin (ADR) 50 mg/m2, intravenous injection, day 1. For patients with residual tumor, 10 times/3 weeks; for patients without residual tumor, 5 times/3 weeks.

2. Immunotherapy

Transfer factor, 1-2 times a week, 1 vial each time. Or use short anaerobic bacteriocin at the same time, starting from 0.1ml/time, once a week, increasing by 0.1ml each time, until 2ml/time, for 2 years.

Once a teratoma is diagnosed, early surgical resection is necessary to prevent benign teratoma from becoming malignant due to delayed surgery, and to prevent infection, rupture, bleeding and complications. The key point of teratoma surgery is to completely remove the tumor. For ovarian and testicular tumors, one ovary or testicle should be removed. For sacrococcygeal teratoma, the coccyx must be removed at the same time to avoid residual pluripotent cells that may cause tumor recurrence.