What is the cause of renal hamartoma

What is the cause of renal hamartoma? What we call renal hamartoma can also be called renal angiomyolipoma in clinical practice, which is a benign tumor. The incidence rate has been increasing in recent years, which may be related to the improvement of diagnostic technology. Renal hamartoma can be an independent disease or it may be accompanied by tuberous sclerosis, the latter of which is a familial hereditary disease. The clinical characteristics are multiple lesions in both kidneys, combined with mental retardation, butterfly-shaped sebaceous adenoma on the face, etc. It is more common in women, and the age of onset is mostly 20-50 years old. However, the vast majority of patients with renal hamartoma in my country do not have tuberous sclerosis.

Renal adenomas may be accompanied by tuberous sclerosis, which is an autosomal dominant gene and a hereditary familial disease. 80% of patients have butterfly-shaped sebaceous adenomas on their faces, and other organs such as the brain, eyes, bones, heart, and lungs also have lesions. Brain development is slow, intelligence is poor, and there are epileptic seizures, which are mostly bilateral kidneys. The vast majority of angiomyolipomas in my country are not accompanied by tuberous sclerosis, and 80% of them are women. The symptoms appear between the ages of 20 and 50, and most of them are after the age of 40.

What is the cause of renal hamartoma?

1. Causes of disease

The cause is still unclear. Renal hamartomas are divided into two types: 1. Those with tuberous sclerosis: no symptoms, bilateral, small tumors, multiple lesions, and young age of onset; 2. Those without tuberous sclerosis: often have conscious symptoms, multiple or single, unilateral, larger tumors, and older age of onset. The above classification is from the 1960s. With the advancement of imaging, especially the popularity of ultrasound examinations, people without tuberous sclerosis can also be found to have bilateral kidneys, multiple lesions, small lesions, and no clinical symptoms. Renal hamartomas currently seen in clinical practice are often discovered accidentally during physical examinations, and the symptoms are not obvious.

2. Pathogenesis

Renal hamartomas are often bilateral, yellow or gray, and often associated with hemorrhage, necrosis, cystic changes, and calcifications. The tumor is named for its 3 major components: blood vessels, adipocytes, and smooth muscle. Although malignancy has been reported, extrarenal or lymph node involvement is currently believed to reflect multicentricity rather than metastasis. There are no adequate criteria for malignancy.

The causes of renal hamartoma from the perspective of traditional Chinese medicine:

1. People who drink excessively and often eat fatty meat, animal offal, scaleless fish or egg yolks. Eating too much fatty and high-cholesterol food can cause dampness and heat in the lower jiao, endogenous phlegm and dampness, and disorder of transportation and transformation, that is, too much new fat tissue, causing excessive fat cells in the body to aggregate and degenerate. The treatment principle is: clearing away heat and dampness, strengthening the kidney and spleen, and softening and dispersing nodules.

2. People who are under too much work pressure, are irritable, and often angry. Because of liver qi stagnation, poor blood circulation, and blocked meridians, normal fat tissue and blood stasis can be intertwined. Over time, connective tissue can form to wrap fat cells and form lipomas. Treatment principles: soothe the liver and regulate qi, activate blood circulation and remove blood stasis, soften and disperse nodules. Through treatment, the meridians are unblocked, menstrual blood is unblocked, and lipomas are dissipated.

3. People who often stay up late and think too much. Because of the damage to the liver and kidney, the liver and kidney yin deficiency, yin and yang imbalance, so that the body's ability to decompose fat decreases, the original fat tissue and the new fat can not be arranged normally, forming abnormal fat tissue, that is, "hamartoma", the treatment principle is: nourish kidney yin, regulate yin and yang balance, soften and disperse nodules.