What is the normal hcg value for hydatidiform mole

In fact, many people do not know much about hydatidiform mole. Hydatidiform mole hCG mainly refers to human chorionic gonadotropin. The normal serum HCG level of non-pregnant women is <75mIU/ml, so these values ​​can be used to make judgments and reduce the harm caused by hydatidiform mole.

1. What is HCG

HCG, or human chorionic gonadotropin, is a glycoprotein secreted by the trophoblast cells of the placenta. It is composed of α and β dimers of glycoprotein. HCG test strips are the most widely used test tools for detecting human chorionic gonadotropin.

HCG determination: Accurate quantitative test of HCG is an important test for the diagnosis and follow-up of hydatidiform mole. The amount of HCG is small at the beginning of a normal pregnancy, reaches a peak at 8 to 10 weeks of pregnancy, and then gradually decreases. After the gestational age (100 days), HCG levels drop significantly. In twin (or multiple) pregnancies, the HCG level is also higher than that in single pregnancies. In hydatidiform mole, the HCG level is much higher than normal and remains at a high level. In normal non-pregnant women, serum HCG levels are <75mIU/ml, and β-HCG is <20mIU/ml. The median serum peak value of normal pregnant women is below 100,000 mIU/ml, and the highest value is 210,000 mIU/ml. However, the serum HCG value of patients with hydatidiform mole is much higher than 200,000 mIU/ml. Therefore, combined with clinical and B-ultrasound, a high value of a single HCG item can confirm the diagnosis of hydatidiform mole. If a quantitative HCG test is performed during periodic follow-up and the HCG value is still high after 14 weeks of pregnancy, the diagnosis can be more clear.

2. What is the normal HCG level for hydatidiform mole?

Vesicular villi are typical products of hydatidiform mole. In addition to hydatidiform mole, choriocarcinoma, ectopic pregnancy and some ovarian tumors can also cause an increase in HCG. The increase in HCG value is not fixed, we can only say whether it is increased or not. The growth rate of the human body is very fast. Your level will not necessarily increase by the same amount as other patients. In addition, the diagnosis of hydatidiform mole does not rely solely on HCG.

Ultrasound examination in early pregnancy, especially transvaginal color Doppler ultrasound examination, can detect abnormal pregnancy early. Nowadays, almost all hydatidiform moles can be detected by ultrasound diagnosis. After evacuation of hydatidiform mole, if weekly measurement of β-hydatidiform mole HCG continues to rise or does not fall for several weeks, it can be diagnosed as gestational trophoblastic tumor. Histologically confirmed choriocarcinoma and/or the presence of metastatic lesions with persistently elevated blood HCG are absolute indications for chemotherapy. A physical examination and tests such as a chest x-ray, ultrasound, CT, or MRI of the brain, chest, abdomen, and pelvis can help identify the disorder. Gestational trophoblastic tumor is extremely sensitive to chemotherapy. Even in high-risk metastatic patients with a mortality rate as high as 90%, the cure rate can reach 92% or even higher after chemotherapy.

Patients with hydatidiform mole should undergo uterine curettage and follow up with blood HCG once a week after surgery until it turns negative. Usually 80% of hydatidiform mole do not require preventive chemotherapy, but about 20% of patients have persistently elevated HCG levels and require several courses of chemotherapy. Preventive or adjuvant chemotherapy (not one course of treatment, but several courses until HCG is undetectable) is only suitable for patients who cannot be followed up.