People may not know about nail matrix nevus, but they may know about onychomycosis. In fact, the symptoms of nail matrix nevus are somewhat similar to those of onychomycosis. Both are a phenomenon of nail disease. The main manifestation of nail matrix nevus is that the nail becomes black or linear. This situation requires treatment. Nail matrix nevus generally does not disappear by itself, so everyone should do early detection and early treatment. The nail matrix nevus is a type of nevus. The most common symptom of nail matrix nevus is the black line on the nail, which can easily turn into melanoma and is easily ignored. Moles are abnormal tissues that appear during human development. The phenomenon of moles is very common in life, and almost every mole has the potential to become cancerous. With the popularization of medical knowledge, people have a more comprehensive understanding of moles and are more vigilant about the cancerous transformation of moles. However, moles in certain special parts of the body are often easily overlooked, the most typical of which is the nail matrix nevus. Causes There are many reasons for the formation of black lines on the nails/nevus. Systemic pigmentary diseases and combined nail pigmentation can be seen in acanthosis nigricans, Addison's disease, Peutz-Jeghers syndrome and vitamin B12 deficiency, Cushing's syndrome after adrenalectomy, or Laugier-Hunziker syndrome. Local inducing factors include trauma, fungal infection, eczematous changes, and subungual hemorrhage. Other factors may be caused by drugs (chemotherapeutic drugs, antimalarial drugs, minocycline or gold preparations) that induce increased melanocyte activity, which can lead to black lines on the nails. Clinically, they should be diagnosed as black lines on the nails. Manifestation edit ① Epithelioid nevus cells are arranged regularly, the epidermis is mildly acanthotic and hyperkeratotic, and the epidermal ridges can be elongated. ② If the nevus cells are close to the dermis or inside the dermis, the nevus cells are spindle-shaped. The cellular nevi in the epidermis contain a large amount of pigment, and the lower the location, the less pigment there is in the cells. ③ Generally, unless there is trauma or malignancy, there is little or no inflammation in the dermis. In addition, according to the location of nevus cells in the skin, they can be divided into junctional nevus, mixed nevus and intradermal nevus. Malignant melanoma is considered when the following situations occur: ① Cells show anaplasia or atypia: mainly enlarged and darkly stained nuclei, and cells of varying sizes; ② Malignant junctional differentiation: nevus cells at the junction of the epidermis and dermis show atypical proliferation, the cells are scattered not into nests, or the nests are fused, and there is continuous proliferation of atypical melanocytes in the basal layer between the epidermal ridges; ③ Atypical nevus cells break through the basal layer and penetrate into the dermis; ④ Except for juvenile melanoma, nuclear mitotic images of nevus cells are generally not seen in the deep dermis. If this phenomenon occurs, it is often a symbol of malignant transformation; ⑤ Tumor cells spread throughout the entire epidermis. |
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