About the relationship between laryngeal cancer and genetics

Laryngeal cancer is hereditary to a certain extent. The familial inheritance of laryngeal cancer is caused by chromosomal aberrations in the human body. It is reminded that each cell of the normal human body has 46 chromosomes. Various carcinogenic factors can cause chromosomal aberrations, making the number and shape of chromosomes different from those of normal cells. This chromosomal aberration is sometimes inherited by offspring, making the next generation likely to develop cancer.

1. Is laryngeal cancer hereditary?

Laryngeal cancer is hereditary to a certain extent. The familial inheritance of laryngeal cancer is caused by chromosomal aberrations in the human body. It is reminded that each cell of the normal human body has 46 chromosomes. Various carcinogenic factors can cause chromosomal aberrations, making the chromosomes different from normal cells in number and shape. This chromosomal aberration is sometimes inherited to offspring, making the next generation likely to develop cancer. In addition, people who are likely to develop cancer do not necessarily get cancer, but they just have a greater chance of getting cancer than ordinary people. Xi'an Traditional Chinese Medicine Cancer Hospital believes that the occurrence of cancer is determined by internal and external factors. Cancer constitution only has certain internal factors. If external carcinogenic factors such as radiation and smoking are added, cancer will occur.

2. Genetic factors of laryngeal cancer

Before the 1980s, the understanding of the causes of tumors focused on environmental factors. In the past 20 years, with the progress of molecular biology research, it has gradually been revealed that most tumors are the result of the interaction of genetic and environmental factors. Laryngeal cancer is one of the common malignant tumors in otolaryngology and head and neck surgery, accounting for 4 to 30 percent of otolaryngology malignant tumors. Although its exact cause is not yet fully understood, preliminary studies have confirmed that the occurrence of laryngeal cancer is related to chromosomal aberrations, oncogene activation, and inactivation of tumor suppressor genes. Due to the abnormality of gene regulatory signals, the cell growth regulatory mechanism is disordered, resulting in cell malignancy. The research results of laryngeal cancer-related genes are of great help in understanding the occurrence, development, and prognosis of tumors, and therefore have become a hot topic in laryngeal cancer research.