1. Hematogenous metastasis: Intrahepatic hematogenous metastasis occurs earliest and is the most common. It can invade the portal vein and form a tumor thrombus. Tumor thrombi that fall off in the liver can cause multiple metastatic lesions. Tumor thrombi that block the main trunk of the portal vein can cause portal hypertension and refractory ascites. After invading the hepatic vein, liver cancer cells can enter the systemic circulation and metastasize outside the liver, with the highest metastasis rate in the lungs. It can also metastasize to various parts of the body through the blood, and is more common in organs such as the adrenal glands, bones, kidneys, and brain. Hematogenous metastasis is common in hepatocellular carcinoma. 2. Lymphatic metastasis: Local metastasis is most common to the hilar lymph nodes, but it can also metastasize to the supraclavicular, para-aortic, pancreatic, splenic and other lymph nodes. Lymphatic metastasis is the most common form of cholangiocarcinoma metastasis, which only accounts for 12.6% of the total metastasis. 3. Planting transfer: Occasionally, if the tumor implants in the retroperitoneum and forms bloody ascites, women may also have ovarian metastatic cancer. 4. Direct infiltration: Liver cancer generally rarely directly infiltrates adjacent organs, but it can occasionally spread and infiltrate adjacent tissues and organs, such as the diaphragm, stomach, colon, and omentum. |
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