What causes coffee stains? I believe everyone wants to know, because more and more people have various coffee spots on their faces, which affects their mood and even their appearance. So let me tell you the reasons for the formation of coffee spots. 1. Café au lait spots often begin in early childhood and are light brown spots with regular edges and varying shapes. They gradually grow larger and increase in number with age. Café au lait spots can appear anywhere on the body, and most individuals with them are normal. Some people believe that when a patient has more than 6 coffee-front spots larger than 1.5 cm in diameter, it indicates the presence of neurofibromas. 2. Café au lait spots are a hereditary skin disease that is generally unrelated to sun exposure. They can be a sign of multi-system diseases, such as neurofibromatosis, Albright syndrome, Watson syndrome, Russell-Silver dwarfism, multiple lentigo syndrome, and ataxia-telangiectasia. 3. Pathological changes include increased epidermal melanin, especially in the basal layer. Giant melanosomes are found in DOPA-stained melanocytes and keratinocytes in the basal layer, and the number of basal layer melanocytes is normal or slightly increased. |
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