Anti-inflammatory for vasculitis

Vasculitis is a very common disease in the human body, which usually occurs in middle-aged people or the elderly. Vasculitis can easily lead to poor blood flow in the blood vessels inside the human body, or necrotic tissue in the blood vessels, leading to blockage, causing blue veins on the skin surface, or obvious protruding blood vessels. People with vasculitis can take anti-inflammatory drugs for treatment, or they can use antibiotics.

How to reduce inflammation of vasculitis?

1. Drug treatment

(1) Dextran-40: Dextran with a molecular weight of 5,000 to 20,000 is administered by intravenous drip. Long-term use may cause bleeding and it is not suitable for patients in the acute development stage or those with ulcer gangrene and secondary infection.

(2) Vasodilators include tolazoline hydrochloride, niacin, and benzylamine hydrochloride.

(3) Antibiotics For patients with local or systemic infections, appropriate antibiotics should be used for treatment.

(4) Glucocorticoids may be considered in the acute phase of the disease, with daily oral prednisone or intravenous hydrocortisone.

(5) Analgesics: For patients with significant pain, various analgesics can be used, or procaine acupuncture injection, intravenous blockade or femoral artery periartery blockade, or even lumbar sympathetic ganglion block or epidural anesthesia can be performed.

(6) For local treatment, sterile bandage can be used to prevent infection in dry gangrene, and Kangfuxin dressing can be applied externally for ulcers.

2. Surgical treatment

If non-surgical treatment fails, lumbar sympathectomy, great saphenous vein graft bypass or arterial thromboendarterectomy can be performed. After the boundaries of extremity necrosis are limited, the wound is expanded and the necrotic tissue is removed under sterile conditions. For those who have developed finger (toe) gangrene, finger (toe) amputation should be considered.

Causes

It is currently believed that this disease is caused by occlusion of small arteries due to spasm and thrombosis, resulting in local ischemia. Half of them are accompanied by Raynaud's phenomenon, which is more common in men and smokers. Smoking is closely related to the course and prognosis of this disease.

Clinical manifestations

This disease is more common in young and middle-aged people, and is prone to occur in the lower limbs. The affected limb shows temporary or persistent pallor, cyanosis, burning and tingling. The skin turns red when the affected limb is hanging and turns white when it is raised. It is followed by numbness of the toes and pain in the calf muscles. The pain is stimulated when walking and disappears when resting. Superficial phlebitis and edema often occur in the calf. During the examination, it was found that the dorsalis pedis artery pulse was weakened or disappeared. As the disease progresses, intermittent claudication and Raynaud's phenomenon may occur, pain may intensify at night, the toes may become extremely painful, the skin may become cyanotic, and then the toe tips may ulcerate or become gangrenous and turn black, gradually spreading to the proximal end.

diagnosis

The diagnosis can be made based on the patient's paroxysmal limb pain, intermittent claudication, weakened or absent dorsalis pedis artery pulse, and migratory superficial phlebitis.

It should be distinguished from occlusive arteriosclerosis. The latter are over 40 years old and often have hypertension, diabetes, hyperlipidemia and coronary atherosclerotic heart disease. The large and medium arteries are often affected, and the disease progresses rapidly. X-rays or vascular color Doppler ultrasound examinations may show calcification in the arterial wall of the affected limb.