What causes bile duct cancer

What causes bile duct cancer? The high incidence of bile duct cancer has caused many high-risk groups to pay close attention to this disease. When bile duct disease becomes cancerous, many of the patient's body functions will be damaged, and abdominal pain, vomiting, and indigestion may occur. Let's take a look at the causes of bile duct cancer.

Causes of bile duct cancer:

Hepatolithiasis: Biliary carcinoma is closely related to hepatolithiasis. In areas where hepatolithiasis is common, the pathological change rate of bile duct carcinoma is also increased. The reason may be that the chronic stimulation of gallstones and inflammation causes the bile duct epithelium to rot, ulcerate and fall off, and the epithelial cancer cells proliferate, resulting in bile duct cancer cells. In addition, the obstruction caused by gallstones and the poor bile discharge, and the increase of bile acid in the bile also play a triggering role.

Congenital bile duct enlargement: This disease can easily cause reflux of pancreatic juice, stagnation of bile, and the formation of stones, which are all causes of bile duct cancer.

Hepatitis virus infection: When the human body is infected with the hepatitis virus, the normal regulatory mechanism of cancer cells is disrupted, and oncogenes are abnormally expressed, resulting in precancerous lesions.

Biliary adenoma: Biliary adenoma is common in the intrahepatic bile duct, among which villous adenoma is the most common, and about 63% of villous adenomas can become malignant.

Primary sclerosing cholangitis

This is an autoimmune disease. A chronic cholestatic liver disease closely related to inflammatory bowel disease. It is characterized by diffuse inflammation, stenosis and fibrosis of the intrahepatic and extrahepatic bile ducts, progressive destruction of the bile ducts, and ultimately leading to cirrhosis, portal hypertension and liver failure. Primary sclerosing cholangitis is generally considered a precancerous lesion of bile duct cancer, and most patients are found to have bile duct cancer within 2.5 years after diagnosis.

The above is an introduction to the causes of bile duct cancer. I hope it will be helpful to you.