What factors induce pituitary tumors

Pituitary tumors have become a disease with a very high incidence rate at present, and its cause has become a problem that many experts are exploring. Understanding the cause of the disease is the key to diagnosis and treatment. The formation of pituitary tumors is caused by many factors. Now I will take you to understand which factors induce pituitary tumors.

1. Genetics such as multiple endocrine neoplasia 1 (MEN1), excessive PROP-1, and transcription factor defects;

2. Hypothalamic lesions such as excess GHRH or CRH, dopamine deficiency, and possible receptor activation;

3. Mutations in somatic signal transduction, such as abnormalities in the action of growth factors and cytokines;

4. Gene activation or disruption of cell cycle regulation;

5. Oncogene loss, oncogene GSP, RAS mutation, PTTG-1;

6. Environmental factors: radiation effects, estrogen application;

7. Damage to surrounding structures of the tumor: As the tumor grows, it invades and compresses surrounding important structures, such as the optic nerve, cavernous sinus, cerebral artery, hypothalamus, third ventricle, brain stem, etc., leading to corresponding functional disorders, manifested as decreased vision, visual field defect, hemiplegia, fixed eyeball, diplopia, intellectual memory disorder, mental changes, headache, hydrocephalus, etc.;

8. Endocrine disorders: Pituitary tumors with secretory functions secrete hyperhormones, causing an increase in the patient's PRL, GH, ACTH, TSH and other hormones, which can cause menstrual disorders, lactation, miscarriage, infertility, sexual dysfunction, obesity, ugly face, gigantism, enlarged hands and feet, increased hair, rough skin, etc.; patients with hypopituitarism will show symptoms of fatigue, fear of cold, etc.

9. Metabolic disorders: decreased blood potassium, sodium, chloride, and calcium, weakness, vomiting, nausea, diarrhea, abdominal distension, multiple spontaneous fractures (mostly ribs and vertebrae). Low immune function: easy to catch colds and cancer. Psychological pressure. Pituitary tumors can occur at any age, but are more common in young and middle-aged people. Because pituitary tumors have serious damage to human growth, development, physical and mental health, fertility, and multi-organ functions, patients with pituitary tumors should actively seek early treatment.

After understanding the above-mentioned knowledge about factors that induce pituitary tumors, we should stay away from the influence of radiation in our daily lives. In addition, we should not drink polluted water and protect our environment, which can effectively play a preventive role.