Adverse reactions of aminophylline

Aminophylline is a drug that is usually used to treat bronchial asthma, obstructive pulmonary emphysema and other diseases. It can also be used to treat high blood pressure, high blood sugar and a symptom of digestive tract ulcer. In fact, we must pay attention to this disease. Suffering from this disease has a great impact on human health and needs active treatment. What are the adverse reactions of aminophylline?

Adverse reactions of aminophylline

Aminophylline tablets are white or slightly yellow tablets and are suitable for relieving wheezing symptoms in bronchial asthma, asthmatic bronchitis, obstructive pulmonary emphysema, etc.; they can also be used for asthma caused by cardiogenic pulmonary edema.

The main ingredient of this product is aminophylline. Taking medicine scientifically is the guarantee of health. The usage and dosage of this product are as follows: 1. Common dosage for adults: oral, 0.1-0.2g at a time, 3 times a day; maximum dosage: 0.5g at a time, 1g a day. 2. Usual dosage for children: Oral administration, 3-5 mg/kg body weight each time, 3 times a day.

Common adverse reactions of aminophylline tablets include:

The toxicity of theanolide often occurs at a serum concentration of 15-20μg/ml, especially at the beginning of treatment. Common symptoms in the early stage include nausea, vomiting, irritability, insomnia, etc. When the serum concentration exceeds 20μg/ml, tachycardia and arrhythmia may occur. When the theanolide in the serum exceeds 40μg/ml, symptoms such as fever, dehydration, and convulsions may occur. In severe cases, respiratory and cardiac arrest may occur, leading to death.

Clinical manifestations of aminophylline poisoning

Aminophylline poisoning is often caused by taking too large a dose at one time or taking the drug frequently in a short period of time. In addition to being related to the dose, poisoning is also significantly related to the speed of administration, especially when the intravenous injection is too fast. It is easily absorbed from the digestive tract after oral administration, reaches the maximum effect in 2 hours, and its toxic effects are the same as those of injectable drugs. The general toxic dose is 17mg~28mg/kg, and the lethal dose is still unclear. Epinephrine and * can increase the toxic effects of aminophylline.

Clinical manifestations

(1) Cardiovascular system: It can strongly excite the heart, causing palpitations, sinus tachycardia, ventricular tachycardia, a sharp drop in blood pressure, shock, ventricular fibrillation and cardiac arrest.

(2) Nervous system: It can excite the central nervous system, causing mental excitement, irritability, headache, dizziness, insomnia, hyperreflexia, tremors, convulsions and coma.

(3) Respiratory system: It can stimulate the respiratory center, causing breathing to deepen and accelerate, and causing asthma attacks to persist.

(4) Metabolic disorders: hyperglycemia, acidosis, hypokalemia, hypocalcemia and hypomagnesemia may occur.

(5) Digestive system: This product is a highly alkaline drug. Oral administration of large doses has a direct stimulating effect on the gastrointestinal tract and can cause nausea, vomiting, abdominal pain, diarrhea, and hematemesis.