Can kidney cancer with fh gene mutation be cured?

The treatment of renal cancer with FH gene mutation requires a personalized plan based on the patient's specific situation. Early detection and comprehensive treatment can improve the cure rate. Treatment methods include surgical resection, targeted therapy and immunotherapy, combined with genetic counseling and regular follow-up.

1. Surgical resection is the main treatment for FH gene mutation renal cancer, which is suitable for patients in the early and locally advanced stages. Radical nephrectomy is the standard procedure, which can completely remove tumor tissue. For some patients, nephron-preserving surgery is also an option to help protect renal function. Close monitoring is required after surgery to prevent recurrence.

2. Targeted therapy targets metabolic abnormalities caused by FH gene mutations and inhibits tumor growth by inhibiting specific signaling pathways. Commonly used drugs include mTOR inhibitors and HIF-2α inhibitors, which can effectively control tumor progression. During treatment, it is necessary to monitor drug side effects and adjust the dosage in a timely manner.

3. Immunotherapy activates the patient's own immune system to attack tumor cells and is suitable for patients with advanced or metastatic disease. PD-1/PD-L1 inhibitors are commonly used drugs that can improve patient survival. Biomarker testing is required before treatment to screen suitable patients.

4. Genetic counseling is crucial for patients with renal cancer and their families with FH gene mutations, and helps to understand the genetic risk of the disease. Genetic testing is recommended to clarify the mutation type and inheritance pattern. For patients with fertility needs, preimplantation genetic diagnosis can be considered to reduce the risk of disease in offspring.

5. Regular follow-up is an important part of the management of renal cancer with FH gene mutation, which helps to detect recurrence or metastasis at an early stage. Follow-up includes imaging examination, laboratory examination and clinical symptom assessment. It is recommended to conduct a comprehensive examination every 3-6 months for more than 5 years.

The treatment of renal cancer with FH gene mutation requires multidisciplinary collaboration, combining multiple methods such as surgery, targeted therapy and immunotherapy, while paying attention to genetic counseling and long-term follow-up to improve treatment efficacy and patient quality of life.