Blocking antibody negative

When it comes to blocking antibody negative, perhaps everyone is not very familiar with it, or perhaps it can be said to be very unfamiliar. But when it comes to miscarriage, everyone is familiar with it, and it is also what most pregnant women worry about. In fact, there are many reasons for women's miscarriage, some are congenital and some are acquired. For example, the lack of blocking antibodies can lead to habitual miscarriage in women, which is also congenital; other collisions are acquired.

This situation is very common in reality. Some people are not incapable of pregnancy, but they will miscarry inexplicably when they are pregnant, and they don’t know the reason. At this time, they should consider whether their own blocking antibodies are lacking. But what exactly is blocking antibody negative? Let me explain below.

In the serum of normal pregnant women, there is a specific IgG antibody against spouse lymphocytes, which can inhibit lymphocyte response (MLR), block the cytotoxic effect of maternal lymphocytes on cultured trophoblasts, prevent helper T cells from recognizing inhibitors of fetal antigens, and prevent the mother's immune system from attacking the embryo. Blocking antibodies produce macrophage migration inhibitory factor (MIF) because lymphocytes stimulated by blocking alloantigens produce macrophage migration inhibitory factor (MIF), so they are called blocking antibodies negative, or simply blocking antibodies.

There are many types of blocking antibodies:

1. Anti-warm B cell antibodies: Anti-HLA-D/DR antibodies on the surface of fetal B lymphocytes;

2. Anti-cold B cell antibodies: non-HLA cold B antibodies;

3. Anti-specific antibodies: Genetic antibodies against HLA-D/DR receptors on the surface of maternal helper T cells;

4. Anti-TLX antibody: It is an antibody against common antigens of villi and lymphocytes, which can block mixed lymphocyte reaction;

5. Anti-Fc receptor antibodies: non-cellular blocking antibodies that block Fc receptors on husband's B lymphocytes;

6. Anti-paternal complement-dependent antibodies (APCA).

So through the above understanding, our female compatriots should pay attention. If someone is prone to miscarriage after pregnancy, do not rush to take medicine. First think about whether it is due to the lack of blocking antibodies in the body. Go to the hospital for examination in time, and then treat the symptoms after the doctor's diagnosis. This will be most beneficial to our own health.