What is the reason for high creatinine

High creatinine means that the creatinine value is higher than the normal value. Creatinine includes blood creatinine and urine creatinine. When something is wrong with the body, creatinine will be high. This is something no one wants to see. When these parameters deviate from normal standards, we must pay attention to it and pay more attention to our bodies so that diseases will stay away from us.

Elevated creatinine generally refers to elevated blood creatinine. The normal value of blood creatinine varies from hospital to hospital. Generally speaking, the normal value of blood creatinine is 44-133μmol/L. When blood creatinine exceeds 133μmol/L, it means that the kidneys are damaged and renal insufficiency or renal failure has occurred. (133μmol/L and above is the inflammatory damage stage, 186μmol/L is the renal function damage stage, and 451μmol/L is the renal failure stage.

Creatinine is a product of human muscle metabolism. In human muscles, creatine is mainly converted into creatinine through irreversible non-enzymatic dehydration reaction, then released into the blood and excreted in urine. Therefore, the reason why blood creatinine is high is closely related to the total amount of muscle in the body and is not easily affected by diet. Creatinine is a small molecule that can be filtered through the glomerulus and is rarely reabsorbed in the renal tubules. Almost all of the creatinine produced in the body daily is excreted in the urine and is generally not affected by urine volume.

Reasons for high urine creatinine: 1. Fatigue, poor rest, and inattention to life details can also cause a transient increase in creatinine.

Reasons for high urine creatinine 2. Water loss in the body, such as fever, sweating, reduced water intake, polyuria leading to blood concentration, reduced renal blood flow, and increased creatinine.

Reason 3 for high urine creatinine: People with existing renal insufficiency, such as combined infections, including colds, pneumonia, intestinal infections, urinary tract infections, etc., may experience elevated creatinine in a short period of time.

Reasons for high urine creatinine 4. Patients with existing kidney disease may have oliguria or even anuria due to relapse of the disease, which may be combined with acute renal insufficiency, leading to elevated creatinine.

Reasons for high urine creatinine 5. Patients with existing kidney disease who use drugs that damage the kidneys may experience elevated blood creatinine, which may even be irreversible.