Is ALT 92 serious?

Alanine transaminase is a common complication at present, which will cause many problems in many people's bodies. Because if it is 92, it means it has exceeded a lot. It is not just high but very high. It will affect the metabolism of the liver and cause problems with liver cell function. At the same time, patients will also suffer from insomnia, general fatigue, and recently feel like not wanting to eat. They will also have abdominal pain and diarrhea.

Normal reference

The normal reference value of alanine aminotransferase is 0-40U/L. A level above 40u/L is considered elevated alanine aminotransferase.

Alanine aminotransferase is mainly present in the cytoplasm of liver cells, and its intracellular concentration is 1000-3000 times higher than that in serum. As long as 1% of liver cells are destroyed, serum enzymes can double. Therefore, alanine aminotransferase is recommended by the World Health Organization as the most sensitive detection indicator for liver function damage.

Basic Introduction

High alanine aminotransferase (GPT, ALT) levels are very common in clinical practice. The liver is the largest detoxification organ in the human body. Whether this organ is normal or not is very important to the human body. Elevated GPT is an important indicator of liver function problems. Among the common factors, various types of hepatitis can cause elevated GPT, which is caused by damage to the liver. Some drugs, such as anti-tumor drugs and anti-tuberculosis drugs, can cause liver damage. Drinking large amounts of alcohol and eating certain foods can also cause short-term damage to liver function[1].

The "Guidelines for the Prevention and Treatment of Chronic Hepatitis B in China" recommends: For patients using nucleoside (acid) analogs for the first time, it is recommended to use drugs with high antiviral activity and low drug resistance. Entecavir tablets can rapidly reduce blood HBV DNA levels, with the virus reduced by more than 5 times after 12 weeks of treatment. After 48 weeks of treatment, HBV DNA levels in 75% of patients can be reduced to below detection levels. Studies have shown that under the same treatment conditions, entecavir tablets represented by Runzhong are the fastest antiviral drugs that can achieve virological conversion to negative among existing antiviral drugs.

Main symptoms

Symptoms of high alanine aminotransferase levels include insomnia, fatigue, poor appetite, low-grade fever, aversion to greasy food, jaundice, nausea, vomiting, abdominal pain, diarrhea, and discomfort in the liver area. Mild symptoms include sweating, drowsiness, thirst, and eye fatigue when reading. Some hepatitis B patients have symptoms of high alanine aminotransferase.

Patients need to be reminded that many people believe that having high alanine aminotransferase means they have hepatitis. In fact, there are many reasons for high alanine aminotransferase, such as drinking, fatty liver, alcoholic liver, myocarditis, influenza, etc. can all cause elevated alanine aminotransferase. To determine whether the symptoms of high alanine aminotransferase are caused by hepatitis, other tests are needed, combined with a comprehensive analysis of medical history, symptoms, and physical signs.