What is the connection between Helicobacter pylori and stomach disease

Infection with Helicobacter pylori can easily lead to some gastrointestinal diseases. There is a great connection between the two. Once infected, it may cause gastritis, peptic ulcers, and lymphoproliferative gastric lymphoma. Therefore, in order to quickly and effectively solve these diseases, we must also pay attention to the correct treatment methods and plans. Antibiotics and therapeutic drugs are essential.

1. Hazards

Helicobacter pylori is a spiral-shaped, slightly anaerobic, Gram-negative bacillus that has very strict growth requirements. It was first successfully isolated from gastric mucosal biopsy tissue of patients with chronic active gastritis in 1983 and is the only known type of microorganism that can survive in the human stomach. Helicobacter pylori disease includes gastritis, peptic ulcer, lymphoproliferative gastric lymphoma, etc. caused by Helicobacter pylori infection. The adverse prognosis of Helicobacter pylori infection is gastric cancer.

2. Treatment Plan

1. Helicobacter pylori infection is curable. The treatment options for Helicobacter pylori positive patients include two major categories. One category is commonly used drugs: 1. A regimen based on antibiotics, supplemented with acid suppressants (bismuth); 2. A regimen based on proton pump inhibitors. Commonly used antibiotics include amoxicillin, gentamicin, clarithromycin and amoxicillin. After going to the hospital for examination, the patient should take the medicine according to the doctor's instructions and check the efficacy in time.

2. There are two other antibiotics. The most commonly used one is amoxicillin, and the other is metronidazole. These three are the options we often use. For patients with gastritis or those with poor economic conditions, this option is easier to use and can achieve 80% eradication. This regimen is not suitable for patients who are allergic to penicillin. Those who are allergic to penicillin can switch to tetracycline drugs, which are also more effective against Helicobacter pylori. They can be used with metronidazole for one week. If there is gastric ulcer, ranitidine or famotidine can be added; then there is Losec. If you are allergic to penicillin, you can switch to tetracycline, and metronidazole can be replaced with clarithromycin.

3. Treatment principles

①Use combined medication, such as the triple therapy commonly used internationally

②The eradication rate of Helicobacter pylori is >80%, preferably above 90%;

③No obvious side effects, good patient tolerance;

④ Financial affordability for patients.