How does alcoholic liver disease come about?

In real life, alcoholic liver disease is a relatively common physical disease. Alcoholic liver disease will not only easily damage physical health, but also easily cause some other complications, which is very bad for the body. There are many causes of alcoholic liver disease. Generally, this is due to excessive drinking or liver disease, which requires timely treatment.

What is the cause of alcoholic liver disease?

Patients with cardiovascular and cerebrovascular diseases and hypertension: moderate drinking helps blood circulation, but excessive drinking may induce cardiovascular and cerebrovascular accidents. Severe cases may cause vasospasm, acute myocardial infarction or blood vessel rupture, cerebral hemorrhage and even sudden death.

Patients with liver disease: The liver is most harmed by excessive drinking. The liver is the largest chemical factory in the human body. People with liver disease have poorer metabolic function of the liver than normal people. If they drink alcohol without restraint, their condition will worsen or even lead to accidents.

Patients with gastrointestinal diseases: Excessive drinking can cause damage to multiple systems and organs of the body, and can cause indigestion, gastritis, gastric bleeding, alcoholic pancreatitis, pancreatic necrosis, etc. Patients with gastric ulcers, gastritis, enteritis, nephritis and other diseases should not drink alcohol, and people with hemorrhoids should not drink alcohol. If you must drink, drink in moderation. Try to eat some dishes or food before drinking. Do not drink on an empty stomach, as it will make you drunk easily and hurt your stomach.

Diabetic patients: Studies have shown that there is a U-shaped relationship between drinking and diabetes. Moderate drinking can reduce the incidence of diabetes, while excessive drinking can aggravate diabetes. It is best for diabetic patients to drink sugar-free dry red wine, avoid strong liquor, avoid drinking on an empty stomach, and certainly not drink excessively. If you really can't refuse the invitation, you can add some boiled water or mineral water to dilute the wine to reduce the alcohol content and calorie content.

Snoring people: Snorers have a narrow upper airway. When they fall asleep after drinking, alcohol has a direct paralyzing and relaxing effect on the upper airway muscles. Therefore, after drinking a lot of alcohol, the brain's awakening response to suffocation and hypoxia becomes dull, and the suffocation time is prolonged, especially in the second half of the night, which can be more serious and may lead to sudden death in sleep.

Alcoholic liver disease test items

1. Routine blood test. Patients with alcoholic liver disease may have leukocytosis, various morphological abnormalities of red blood cells, including target cells, macrocytes, thorny cells and stomatocytes, increased mean corpuscular volume (MCV), and may have thrombocytopenia due to the direct toxic effects of alcohol on the bone marrow or secondary hypersplenism.

2. Liver function test. Patients with alcoholic liver disease will have elevated serum bilirubin and significantly increased aspartate aminotransferase (AST) activity, while alanine aminotransferase (ALT) activity is only slightly elevated or normal. Therefore, when the AST:ALT ratio increases and the ratio is >2, the sensitivity for diagnosing alcoholic liver disease is 68%, the specificity is 91%, and the positive predictive value is 82%. The activities of alkaline phosphate and r-glutamyl transpeptidase (r-GT) were increased. r-GT is a sensitive but not specific indicator. The combined detection of MCV, rG and alkaline phosphatase is an ideal laboratory indicator for diagnosing alcoholic liver disease.

3. Ultrasound and CT examination of the liver. CT plain scan is used for clinical diagnosis of alcoholic fatty liver, and the liver-spleen density ratio can be used as a reference standard for measuring alcoholic fatty liver or as a basis for follow-up efficacy. Some patients were also found to have alcoholic hyaline bodies (Mallory bodies) after liver biopsy, accompanied by cell necrosis with neutrophil infiltration, and ballooning of hepatocytes.