What's wrong with high bilirubin aminotransferase

Bilirubin and transaminase are important indicators for measuring liver function. In daily life, when we check liver function, we usually test these two data and analyze them according to different situations. However, some people have high bilirubin and transaminase levels, and they must be worried about their health problems. So, what's the matter with high bilirubin transaminase? Let’s take a look below.

Causes of high total bilirubin

1. Generally speaking, an increase in total bilirubin is caused by liver problems, such as acute or chronic icteric hepatitis, cirrhosis, or adverse reactions caused by blood type incompatibility during blood transfusion, or toxic hepatitis can also cause an increase in total bilirubin.

2. High bilirubin levels indirectly increase. Because the patient suffers from some hemolytic diseases, excessive damage to the red blood cells in the body will occur, causing an increase in total bilirubin. If there is a incompatibility between the blood types of the mother and the fetus during pregnancy, it will also lead to an increase in total bilirubin.

3. Direct increase in total bilirubin. If you suffer from cholelithiasis or liver cancer caused by obstruction of the bile duct, it will cause obstructive jaundice, which will directly lead to an increase in total bilirubin.

Causes of high transaminase

reason

Non-pathological

1. If a healthy person checks his transaminase after strenuous exercise, he will find that his transaminase level is elevated.

2. If you are too tired, it will cause an increase in transaminase.

3. Eating greasy food or drinking alcohol before the examination will cause elevated transaminase levels.

4. Pregnant women may also suffer from endocrine disorders, which may lead to elevated transaminase levels;

5. Malnutrition and unreasonable diet structure, such as a low-protein diet, especially when the food lacks cysteine ​​and vitamin E, can also cause ALT to rise.

6. The side effects of daily medications can also lead to elevated transaminase levels, such as erythromycin, sleeping pills, antipyretic analgesics, contraceptive ointments, and Chinese medicines such as Pinellia, Areca, and Indigo.

Pathological

1. Viral hepatitis is a common disease that causes high transaminase levels. Other types of hepatitis can also cause high transaminase levels.

2. Many drugs and chemical agents can cause high levels of transaminase, but they will return to normal after stopping the medication.

3. Cirrhosis and liver cancer When cirrhosis is active, high transaminase levels usually occur.

4. Acute attacks of biliary diseases such as cholecystitis and cholelithiasis may cause high blood bilirubin and transaminase levels in addition to fever, abdominal pain, nausea, vomiting, jaundice, etc. Transaminase is excreted from the bile duct. If there are diseases of the bile duct, gallbladder, and pancreas, or bile duct obstruction, the transaminase level may also increase. Common diseases seen in hospital beds include cholecystitis, bile duct ascariasis, hepatobiliary stones, gallbladder and bile duct tumors, periampullary cancer, congenital biliary dilatation, acute and chronic pancreatitis, pancreatic headache, and hemorrhagic necrotizing pancreatitis.

5. Heart disease: Acute myocardial infarction, myocarditis, and heart failure can cause high levels of transaminase.

6. Certain other infectious diseases: In addition to the liver, other organs and tissues in the body such as the heart, kidneys, lungs, brain, testicles, and muscles also contain this enzyme. Therefore, elevated blood transaminase levels may also be seen in patients with myocarditis, pyelonephritis, lobar pneumonia, tuberculosis, polymyositis, hyperthyroidism, acute sepsis, typhoid fever, meningitis, malaria, leptospirosis, influenza, measles, schistosomiasis, crush syndrome, etc.

7. Have you taken any drugs that are harmful to the liver? If so, be sure to pay attention to the possibility of drug-induced hepatitis;

8. Women should also pay attention to the possibility of autoimmune hepatitis and check whether autoimmune antibodies (antinuclear antibodies, anti-smooth muscle antibodies, etc.) are positive;

9. Have you ever had cholecystitis, heart disease, nephritis or other diseases in the past? These diseases can also cause elevated transaminase levels.

To sum up, there are many reasons for elevated transaminase levels, and careful examination is necessary to identify the cause and treat it accordingly.

A transaminase level between 0 and 40 is normal. If it is outside the normal range, the doctor will recommend another check to rule out the possibility of errors caused by factors such as laboratory equipment failure and operating errors. If the transaminase level is still high, it is most likely caused by viral hepatitis or other liver disease. However, to determine whether it is viral hepatitis, other tests are needed, combined with a comprehensive analysis of medical history, symptoms, and physical signs.