What diseases can prostate cancer be confused with

With the change of eating habits, the incidence of prostate cancer is getting higher and higher. It brings great pain and distress to human beings. Its pathogenic factors are very complex and should be discovered and treated early. Therefore, it must be differentiated from some diseases to make a clear diagnosis.

(1) It should be differentiated from prostate hyperplasia: The two are generally easy to distinguish. However, in the hyperplastic prostate gland, the epithelial cells in some areas are atypical in morphology and can be mistaken for cancer. The key points of differentiation are: the alveoli in the hyperplastic gland are larger, the surrounding collagen fiber layer is intact, the epithelium is double-layered and high-column, the cell nucleus is smaller than that of prostate cancer patients and is located at the base of the cell, the glands are arranged regularly, and obvious nodules are formed.

(2) Differentiation from prostate atrophy: Prostate cancer often starts from the atrophic part of the gland, so it should be carefully differentiated. Atrophic alveoli are sometimes tightly clustered, atrophic and smaller, and the epithelial cells are cubic with large nuclei, which is very similar to cancer. However, this type of atrophy often involves the entire lobule, the collagen connective tissue layer is still intact, the matrix is ​​not invaded, but it itself is sclerotic and atrophic.

(3) Differentiation from prostate squamous epithelium or transitional epithelium metaplasia: It often occurs in the healing part of the infarct area within the gland. The squamous epithelium or transitional epithelium is well differentiated and has no degeneration or split phase. The most prominent feature of metaplasia is ischemic necrosis or a fibrous connective tissue matrix lacking smooth muscle.

(4) Granulomatous prostatitis: The cells are large and may aggregate into sheets. They have transparent or light red stained cytoplasm and small vesicular nuclei, which are very similar to prostate cancer, but are actually macrophages. Another type of cells are polymorphic, with condensed and vacuolated nuclei, small in size, arranged in rows or clusters, and sometimes some alveoli can be seen. When distinguishing, it should be noted that there are very few alveoli in granulomatous prostatitis, and the relationship between the lesions and normal glandular ducts is unchanged. Degenerative amyloid bodies and multinucleated giant cells are often seen. In contrast, the cells of prostate cancer are low columnar or cubic, with clear cell walls, dense eosinophilic cytoplasm, larger nuclei than normal, and may have variations in staining and morphology, and inactive division. Its alveoli are smaller, lack convoluted tubules, completely lose their normal arrangement, irregularly infiltrate the matrix, and the collagen connective tissue layer no longer exists. The alveoli contain a small amount of secretions, but rarely amyloid bodies. If prostate cancer undergoes obvious degeneration, the tissue structure will completely disappear, and there will be no tendency for alveolar formation.

(5) In addition, prostate cancer should be differentiated from prostate tuberculosis and prostate stones. See the relevant section for details.

The above is an introduction to the relevant knowledge of "what diseases can be confused with prostate cancer". I hope it can be helpful to everyone. Experts suggest: If you have symptoms of disease in your health, do not delay diagnosis and go to a regular hospital for treatment in time to avoid delaying the disease and causing serious consequences. If you have other questions, please consult our experts online.

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