Causes of pancreatic cancer

The incidence of pancreatic cancer remains high. Now, many people suffer from pancreatic cancer. However, many people do not know much about the causes of pancreatic cancer and the situation of pancreatic cancer, which makes it very difficult to detect and treat pancreatic cancer in its early stages. Therefore, it is very important to understand the causes of pancreatic cancer and prevent it.

Diabetic patients who smoke a lot for a long time and eat a high-fat, high-animal protein diet have a relatively higher incidence rate. This disease is more common in middle-aged and elderly people. Male patients are far more common than premenopausal women, and the incidence rate of postmenopausal women is similar to that of men. So what are the common causes of pancreatic cancer?

Common causes of pancreatic cancer include:

1. Helicobacter pylori

(Hp) studies have shown that Hp seropositivity results were significantly different among pancreatic cancer patients compared with the control group, suggesting that Hp infection is associated with pancreatic cancer.

2. Chronic pancreatitis

Most epidemiological and molecular epidemiological studies support that chronic pancreatitis can develop into pancreatic cancer. Friess's study showed that among 5,600 genes, 34 genes were expressed less in patients with pancreatic cancer and chronic pancreatitis, 157 genes were expressed more strongly in chronic pancreatitis, and 152 of them were also expressed more strongly in pancreatic cancer. This study proved at the molecular level that there may be some connection between chronic pancreatitis and pancreatic cancer.

3. Coffee

The survey found that coffee can increase the risk of pancreatic cancer by 4 times. Studies have shown that coffee can inhibit DNA repair and induce mitosis before DNA replication is completed, which is the main cause of cancer.

4. Genes

Relationship with pancreatic cancer The role of Notch, ras, p53, TGF-β, DPC4, apoptosis-related genes in pancreatic cancer is very complex, but the exact mechanism is still unclear. The occurrence and development of tumors is a complex multi-stage process caused by abnormal expression of multiple tumor-related genes or inactivation of many tumor suppressor genes. DNA chip technology can directly detect the types and abundance of mRNA, and is a powerful tool for studying gene expression.

The above is the knowledge about the prevention of pancreatic cancer patients introduced by pancreatic cancer experts, so I hope everyone can stay away from these causes of pancreatic cancer. I hope it will be helpful to everyone. Once you have pancreatic cancer, you must go to the hospital for treatment in time to avoid serious delays in the disease.