How high is the hereditary rate of uterine cancer

If there is a family member with uterine cancer, such female friends will worry whether it will be passed on to the next generation. The correct name is uterine body cancer or endometrial cancer, which mainly occurs in the uterus and is different from cervical cancer. Uterine cancer is the second most common cancer that troubles women, second only to breast cancer. So is uterine cancer really hereditary?

In fact, it is generally not hereditary. It’s just that if there is a family history of the disease, the chance of getting the disease is slightly higher than that of normal people. In addition, the chance of uterine fibroids becoming malignant is extremely small.

The sensitivity of endometrial cancer to endometrial cancer is related to the level of estrogen in the endometrium that is not antagonized by progesterone. The reason is simple: as cells divide rapidly, the chances of cancer cells mutating increase, and while estrogen stimulates cell division, progesterone inhibits it. Hormone replacement therapy for postmenopausal women, using a combination of estrogen and progesterone, reduces the risk of endometrial cancer. However, women taking hormone replacement therapy should be checked regularly for signs of endometrial cancer.

Cervical cancer refers to a malignant tumor that occurs in the vaginal part of the uterus and the cervical canal. The metastasis of cervical cancer can spread directly to adjacent tissues and organs, downward to the vaginal vault and vaginal wall, upward to the uterine body, to the sides to invade the pelvic tissue, forward to invade the bladder, and backward to invade the rectum. It can also metastasize to the paracervical, internal iliac, external iliac, and inguinal lymph nodes through the lymphatic vessels, and in the late stage it can even metastasize to the supraclavicular and other lymph nodes throughout the body. Hematogenous metastasis is relatively rare, and common metastatic sites are the lungs, liver, and bones. Three months after the onset of symptoms of cervical cancer, 2/3 of patients have advanced cancer.