How does pancreatic cancer develop

Pancreatic cancer is a disease with very complex causes. It is not easy to recover after it occurs. It is even more necessary to understand the relevant common sense and actively prevent and treat pancreatic cancer. Let me tell you what are the causes of pancreatic cancer?

1. Smoking a lot. Studies have found that there is a close connection between pancreatic cancer and smoking. ① Smoking promotes the excretion of tobacco-specific N-nitrite, a carcinogen, into the bile duct, which then flows back into the pancreatic duct. ② Tobacco-specific N-nitrite can flow into the pancreas with the blood after specific infection of organs. ③ Smoking increases blood lipid levels and promotes pancreatic cancer. Smokers may be prone to cancer due to low cell methylation levels. Experiments have shown that maintaining adequate levels of folic acid and pyridoxal can reduce the harmfulness of pancreatic cancer related to smoking.
2. Studies on diabetes experiments show that insulin can promote the growth of pancreatic cancer cells in vitro or in vivo. High concentrations of insulin can activate the insulin-like growth factor-1 receptor, producing a growth-promoting effect including changes in the cell cycle process.
3. Most studies on the epidemiology and molecular epidemiology of chronic pancreatitis support that chronic pancreatitis can develop into pancreatic cancer. Friess's study showed that among 5,600 genes, 34 genes had reduced expression in patients with pancreatic cancer and chronic pancreatitis, 157 genes had increased expression in chronic pancreatitis, and 152 of them were also increased in pancreatic cancer.