What is the cure rate for various stages of testicular cancer?

Everyone should know the clinical staging of testicular cancer, because knowing the cure rates of various stages of testicular cancer can help patients prepare for the treatment of the disease. In fact, testicular cancer patients should know more about the basic knowledge of the disease, which will help improve the cure rate of testicular cancer. What is the cure rate of various stages of testicular cancer?

Treatment of clinical stage Ⅰ testicular seminoma

Any testicular tumor should be treated with high-position orchiectomy first, and then the treatment plan should be selected according to the pathological type and clinical stage. Spermatogonia are highly radiosensitive, and a lower dose can eliminate metastatic lesions without causing obvious radiation damage. For clinical stage I testicular seminoma, after high-position orchiectomy, the ipsilateral iliac lymph nodes and retroperitoneal lymph nodes should be preventively irradiated. Linear accelerator high-energy rays, 60Co and kilovoltage X-rays can all be used as external radiation sources. However, high-dose preventive irradiation is not necessary.

Treatment of clinical stage Ⅱ testicular seminoma

In clinical stage IIa, the retroperitoneal metastatic lymph nodes are small, and the irradiation field is the same as that in clinical stage I. In clinical stage IIb, the metastatic lymph nodes are large, and the irradiation field should be designed according to the size of the metastatic lesions to fully include the lymph nodes. For patients with extensive abdominal metastasis, whole abdomen irradiation should be performed. The dose fractionation of radiotherapy for clinical stage II is the same as that for clinical stage I. After irradiating the mid-plane dose of 25Gy, the metastatic lymph nodes are enhanced with a reduced field of 10Gy in stage IIa, and the total mid-plane dose should reach 35Gy/4~5 weeks or more; the enhanced irradiation in stage IIb is 15Gy, and the total dose reaches 40Gy. Whether clinical stage II testicular seminoma requires preventive radiation in the mediastinum and left supraclavicular region is still controversial.

Treatment of clinical stage Ⅲ and Ⅳ testicular seminoma

Clinical stage II, III and IV testicular seminoma all require a combination of radiation and chemotherapy. The treatment of stage III cases is the same as that of stage II, but the radiation dose to the metastatic lymph nodes in the mediastinum and left supraclavicular region should reach 35~40Gy/5~6 weeks. For clinical stage IV cases with distant metastasis before treatment, chemotherapy should be the main treatment, supplemented by radiotherapy to control local lesions, and no preventive radiation should be performed. The treatment is reasonable to use chemotherapy-radiotherapy-chemotherapy, that is, the "sandwich" technique, that is, 3 courses of chemotherapy first, followed by irradiation of 35~40Gy/5~6 weeks, and then 3~4 courses of chemotherapy.

Testicular seminoma is sensitive to a variety of anti-tumor drugs. my country's first N-formyl sarcolytic agent is used to treat testicular seminoma. 150-200 mg is taken every night before bedtime, and 6-8 g is a course of treatment. The total effective rate is 91.3%, of which 2/3 are completely relieved. Recently, PVB or VAB-6, PVP16 combined chemotherapy is mainly used, and the cure rate of stage III cases has reached 90%.

The above is an introduction to the “cure rates of testicular cancer in various stages”. After a detailed understanding of the treatment of testicular cancer, since many cases have shown serious recurrence, I hope that everyone will make more cautious choices and choose truly effective fundamental treatment methods.