Haptoglobin is high

Haptoglobin, also known as haptoglobin, is an important globulin in our liver. If our liver is inflamed, the value of this protein will increase because it occupies a part of our plasma and easily forms a compound with our hemoglobin. It is also very important for our body. So why is the haptoglobin high?

Haptoglobin, also known as haptoglobin, is an α2 globulin synthesized by the liver, accounting for about 1% of the total plasma protein. It can combine with hemoglobin in plasma to form a certain complex.

Protein typing

When hemolysis occurs, the free hemoglobin in the plasma increases, the globin bound to it increases, and the plasma haptoglobin decreases. This is a very sensitive indicator of intravascular hemolysis.

Haptoglobin typing: HP1-1, HP2-1, HP2-2, HP0. These four types are classified according to the difference in α subunits. Among them, HP0 is quite special and appears in leukemia patients [1].

Normal value

Rocket electrophoresis: 1.0-2.7g/L;

Radial immunodiffusion method: 0.8-2.7 g/L;

Hemoglobin binding method: 0.3-2.0g/L;

Clinical significance

Decreases seen in:

1. Clinically, Hp measurement is mainly used to diagnose hemolytic anemia. The Hp content in various hemolytic anemias is significantly reduced, even to the point where it cannot be detected. In mild hemolysis, all free Hb in the plasma combines with Hp and is cleared. At this time, free Hb cannot be detected in the plasma, and only a decrease in Hp is seen. It is detected when the amount of free Hb exceeds the Hp binding capacity. Therefore, a decrease in Hp can be used as a sensitive indicator for diagnosing mild hemolysis.

2. Hp is reduced in acute and chronic hepatocellular diseases (such as hepatitis).

3. In infectious mononucleosis and congenital ahaptoglobinemia, Hp may decrease or be absent.

4. Acute and chronic infections, tissue damage, malignant diseases, etc. may also increase the level.

5. Megaloblastic anemia.

Elevated levels are seen in:

1. The serum Hp level in patients with extrahepatic obstructive jaundice is normal or elevated;

2. Trauma and burns;

3. Malignant tumor;

4. Acute and chronic infection;

5. Tuberculosis;

6. Rheumatic diseases, such as rheumatic arthritis, rheumatoid arthritis, and lupus erythematosus;

7. Coronary heart disease;

8. Nephrotic syndrome;

9. People with endocrine disorders, those using contraceptives or steroid drugs, and women with normal pregnancy.