Comprehensive understanding of Alzheimer's disease

We are not unfamiliar with the disease of Alzheimer's disease, so what exactly is Alzheimer's disease? How much do we know about it? In our daily life, we often see some phenomena of senile dementia, but it is very different from early-onset dementia. Today we will discuss the knowledge about early-onset dementia, strengthen our understanding of this aspect, improve our awareness of it, and protect our health.

1. Basic Overview

Alzheimer's disease is a type of senile dementia, which is generally divided into two types: cerebrovascular dementia and Alzheimer's dementia. "Alzheimer's dementia" is also known as senile dementia.

With the aging of the population structure, the number of patients with Alzheimer's disease has increased, which not only brings pain to the patients, but also brings many problems to their families and society.

2. Pathology

Typically, Alzheimer's disease is a disease that develops with aging and rarely runs in families. It is produced as people age. Amyloid precursors are synthesized in the brain and then broken down by protein enzymes into water-soluble amyloid proteins. The proteins then react to form amyloid fibers, which are deposited in the narrow gaps between the synapses of nerves and nerve cells, causing abnormalities in nerves and nerve cells, and causing people to suffer from Alzheimer's disease.

Compared with normal healthy elderly people, the concentration of acetylcholine and the number of nicotinic acetylcholine receptors in the brain of patients with Alzheimer's disease are reduced. If the nerve cells in an organism are lacking, it will be difficult to complete the task of transmitting information. When the message reaches the endings of nerve cells, chemicals called neurotransmitters are released. After this neurotransmitter binds to the receptor, it transmits the information to the next nerve cell, and acetylcholine is one of the most important neurotransmitters.

The effect of nicotinic alkaloids on spatial recognition function was tested on rats with partial brain damage. The results showed that the learning ability of rats with partial brain damage was significantly improved by feeding them nicotinic alkaloids, and the ability was able to reach a level similar to that of normal rats. Moreover, the effect of a single dose can last for 15 days. Therefore, stimulating nicotinic acid receptors is effective in treating perceptual disorders in patients with Alzheimer's disease.

Some researchers used statistical analysis methods and came to the statistical conclusion: there is a significant inverse correlation between smoking and Alzheimer's disease. The more people smoke and the longer their smoking history, the lower their risk of developing the disease. If the smoking history and family history of dementia are linked for analysis, the inverse correlation is stronger for those with a family history of dementia, meaning the risk of developing the disease is the lowest; in the survey group without a family history of dementia, the same trend is reflected in that the higher the smoking level, the lower the risk of developing the disease.

A research team in the Netherlands used 200 patients with Alzheimer's disease and 200 healthy people of the same age and gender as controls to study the age of onset of dementia and the relative risk of Alzheimer's disease.

3. How to prevent Alzheimer's disease? Prevention of Alzheimer's disease should start from middle age, and specifically pay attention to the following points. 1. Cultivate good psychological qualities and establish a good world outlook, analyze everything happening around you realistically and scientifically, and deal with it calmly and properly, avoid the generation of psychological deviations such as extremism and stubbornness, and ensure that psychological reactions are moderate. Participate in work and study within your ability to gain psychological satisfaction and prevent loneliness. Cultivate hobbies and enhance the interest of life.

The above is some knowledge about Alzheimer's disease. From it we can see that Alzheimer's disease becomes more and more common with age, which has a great impact on our physical health. The cause of Alzheimer's disease is closely related to some small details in our lives. For our health, we need to strengthen our understanding of this aspect. I hope that some of the common sense provided above can help you and let us say goodbye to Alzheimer's disease!