The role of gangliosides

We may not fully understand the meaning behind this unfamiliar word, so let me explain it briefly. Gangliosides are sphingolipids containing sialic acid. Kroenke was the first to discover that gangliosides accumulate in the brains of children with Tay-sachs disease (Tay-sachs juvenile dementia), and that the content is high in the gray matter of the brain, so this type of glycolipid was named ganglioside. Let’s take a look at the effects of gangliosides.

A concept

Non-neural gangliosides found in the matrix of horse blood cells by Tamao Yamakawa (1951) - mainly hematoside [hematoside, with the structure of ceramide (1←1β)GLc (4←1β)Gal (3←2α)sialic acid]. Gangliosides are present in large quantities in cell membranes and have attracted much attention due to their relationship with membrane function. The exotoxins of tetanus and cholera can specifically bind to specific ganglioside molecules. Soluble in water and organic solvents. In water, it exists in the form of micelles composed of millions of molecules.

Second effect

1Gangliosides have a significant promoting effect on nerve regeneration. Dr. Gatte Walker, chief scientist of the Brain Science Research Laboratory of Canada Jinjue Group, further discovered that nerve growth factor (NGF) and ganglioside (GM) are essential substances for the regeneration and development of brain nerves. GM mediates NGF to enhance its activity dozens of times, forming a new and rich neural network, repairing and promoting the development of brain nerves again.

2GM can mediate nerve growth factor NGF to promote brain nerve cell regeneration and show good biological effects. ——"Journal of Xi'an Jiaotong Medical University"

3NGF and GM have shown the effect of promoting recovery of the nervous system both in experiments and clinical practice, and have become a hot topic of research. If the synergistic effect of these two drugs can be fully utilized, it will definitely bring greater hope to patients with central nervous system diseases. ——Department of Neurosurgery, Affiliated Hospital of Shandong Medical University.

After reading the above explanation of gangliosides, the main function of gangliosides is to promote the regeneration of brain nerve cells, which should be great news for patients with central nervous system diseases. In this way, their damaged nerves will be regenerated and they will regain health. Such a discovery is also a major medical breakthrough. It brings good news to many patients with neurological diseases.