What is the clinical definition of liver fibrosis determination

Lung function diseases are very harmful to our body because the main function of the lungs is breathing. If the respiratory function is affected by lung function diseases, then there will be many problems with the gastrointestinal function. The determination of liver fibrosis is an examination technology that can determine whether the lung function is healthy or whether there is disease. However, there are many precautions in these aspects, and some people cannot do it.

Normal value

(1) PCⅢ (type III procollagen): normal range <18 ng/mL. (2) IV-C (type IV collagen) normal range is 30-140 ng/mL. (3) LN (laminin): normal range 50-180 ng/mL. (4) HA (hyaluronidase): normal range <120ng/mL. (5) Prolidase (PLD): normal value 1107±19.5u/L. (6) Monoamine oxidase (MAO): normal value 3.3-15.1nmol/(s·L).

Clinical significance

Abnormal results: (1) Slow-acting liver with continuous increase in PCIII indicates that the condition may worsen and develop into cirrhosis. (2) Increased levels of IV-C (type IV collagen) can reflect the degree of liver fibrosis. As the disease progresses from chronic liver disease to chronic active liver disease to cirrhosis to liver cancer, the serum content of IV-C collagen gradually increases. (3) The higher the LN level, the more significant the esophageal varices in patients with cirrhosis. (4) Blood HA levels are higher than 100 μg/L, indicating the presence of liver cirrhosis and liver fibrosis. (5) The CG of patients with acute hepatitis, chronic active hepatitis, cirrhosis and primary liver cancer was significantly higher than that of the normal control group. (6) In quiescent chronic hepatitis and cirrhosis, ALT is normal, but PLD is significantly elevated. Therefore, PLD is a good indicator of acute liver damage and progressive liver fibrosis. (7) Increased MAO levels in patients with liver cancer indicate that the patients also have liver cirrhosis. (8) During liver fibrosis, the amount of PINP synthesis increases, causing changes in the concentration of PINP in serum. People who need to be examined: patients with liver fibrosis and cirrhosis.

Precautions

Unsuitable people: None. Pre-examination contraindications: (1) Be careful not to take medications before the examination, because some medications will increase the burden on the liver and cause temporary damage to liver function, thereby affecting the accuracy of liver function test results. (2) Before the examination, you should make sure to get enough sleep and avoid strenuous exercise, as this may cause elevated transaminase levels and affect the examination results. (3) Do not drink alcohol the day before the test, as drinking alcohol will cause an increase in transaminase and affect the test results. (4) The patient's consent was obtained when undergoing liver biopsy. Taboos during the examination: (1) Do not eat before the examination. Blood tests require fasting, and the fasting time is generally 8-12 hours. (2) Be careful not to injure the patient when performing liver puncture biopsy. (3) Because a single indicator can only reflect one aspect of the generation and degradation of liver fibrosis and because connective tissue is easily affected by systemic metabolism. Therefore, the combined detection of several indicators can achieve satisfactory sensitivity and specificity.

Inspection process

6 ml of venous blood was drawn and tested in ordinary tubes for the concentrations of CⅢ (type III procollagen), IV-C (type IV collagen), LN (laminin), HA (hyaluronidase), CG (glycocholic acid), PLD (proline peptidase), MAO (monoamine oxidase), and PINP (type I procollagen amino-terminal peptide).

Related diseases

Liver fibrosis, portal hypertension, hepatitis C virus infection and glomerulonephritis, liver cirrhosis in the elderly, congenital liver fibrosis, liver cirrhosis in children

Related symptoms

Liver dysfunction, enlarged and hard liver, hard liver texture, biliary cirrhosis, alcoholic cirrhosis