What are the effects of neostigmine methylsulfate?

Neostigmine methylsulfate is a common liquid medicine in medicine and is an injection solution. The main function of neostigmine methylsulfate is that it can be used for severe muscle weakness after surgery to improve intestinal flatulence and urinary retention. It can be injected through the human vein and needs to be injected in an appropriate amount. Excessive dosage may easily cause adverse reactions.

What is the effect of neostigmine methylsulfate?

Ingredients

The main ingredient of this product is neostigmine methylsulfate

Chemical name: N,N,N-trimethyl-3-[(dimethylamino)formyloxy]anilinium methyl sulfate.

Chemical structure:

Molecular formula: C13H22N2O6S

Molecular weight: 334.39

Excipients: Water for injection

Characteristics

This product is a colorless clear liquid.

Indications

Anticholesterase drugs. It antagonizes the residual muscle relaxant effect of non-depolarizing muscle relaxants at the end of surgery and is used for myasthenia gravis, postoperative functional intestinal flatulence and urinary retention, etc.

Specification

1ml;0.5mg

Dosage

The usual dose is 0.25-1 mg per subcutaneous or intramuscular injection, 1-3 times a day.

The maximum dose is 1 mg per subcutaneous or intramuscular injection, 5 mg per day. (It should be clear whether it can be injected intravenously and the dose of intravenous antagonist muscle relaxant should be stated)

Adverse Reactions

This product can cause drug rash. Large doses can cause nausea, vomiting, diarrhea, tearing, salivation, etc. In severe cases, ataxia, convulsions, coma, slurred speech, anxiety, fear and even cardiac arrest may occur.

Taboo

(1) It is contraindicated for people with allergies. (2) It is contraindicated for patients with epilepsy, angina pectoris, ventricular tachycardia, mechanical intestinal obstruction, urinary tract obstruction, and asthma. (3) It is contraindicated for patients with arrhythmia, sinus bradycardia, decreased blood pressure, or increased vagal tone.

Precautions

(1) In case of overdose, atropine is routinely given to counteract it.

(2) Use with caution in patients with hyperthyroidism and Parkinson’s disease.

Pregnant and lactating women

Not yet clear.

Children's medication

Not yet clear

Medication for the elderly

Not yet clear.

Drug interactions

(1) This product should not be used in combination with depolarizing muscle relaxants.

(2) Certain drugs that can interfere with muscle transmission, such as quinidine, can weaken the effect of this product and should not be used together.