What is the function of potassium tablets

Taking medicine is the most common way to treat diseases in people's daily lives. Compared with injections or infusions, taking medicine may be slower to take effect, but it is the most convenient way. You can take the medicine some time after a meal. There are many types of drugs, and glucosamine sulfate potassium tablets are a very common one. It has many functions. The following is a detailed introduction to its functions.

Oral administration of this product can increase the absorption of tetracycline drugs in the gastrointestinal tract and reduce the absorption of oral penicillin or chloramphenicol. This product can be used simultaneously with steroidal or non-steroidal anti-inflammatory drugs.

Pharmacology and Toxicology

Pharmacological action: Glucosamine is a natural amino polysaccharide and a basic component of articular cartilage. This substance promotes the synthesis of chondrocytes and protects them from damage by destructive enzymes. It stabilizes cell membranes and intracellular collagen, and thus has a protective effect on cartilage at rest, in motion, and in recovery, thereby delaying the pathological process and progression of osteoarthritis, improving joint movement, and relieving pain.

Pharmacokinetics

According to literature, in animal experiments, the use of 14C-labeled glucosamine sulfate revealed that glucosamine sulfate has a special affinity for articular cartilage. It has been confirmed that glucosamine sulfate does not bind to plasma proteins of mice, dogs, and humans in vitro. 14C-labeled glucosamine sulfate was administered to humans via oral, intramuscular, and intravenous administration. After entering the human body, glucosamine sulfate was rapidly absorbed and decomposed into D-glucosamine and sulfate ions. After 1 to 2 hours, the radioactivity of glucosamine almost completely disappears, and it is replaced by radioactivity derived from plasma γ-globulin, indicating that glucosamine and its derivatives are bound to plasma γ-globulin. This radioactivity reaches a peak 8 to 10 hours after administration, with a half-life of 70 hours. After 120 hours, 28% of the radioactivity is excreted from the urine, and less than 1% of the radioactivity is excreted from the feces. Results after IM injection are similar to those after IV injection.

After oral administration, 90% of glucosamine sulfate is rapidly absorbed by the gastrointestinal tract. Free glucosamine sulfate cannot be detected in plasma. The pharmacokinetics of plasma protein radioactivity are similar to those of intramuscular and intravenous injections, but plasma concentrations are 5 times lower than those of intravenous injections. The AUC of the drug when taken orally is 26% of that when injected intravenously or intramuscularly. This may be due to the first-pass effect of the drug entering the human body. In the liver, most of the glucosamine sulfate is broken down into small molecules and ultimately into CO2, water and urea.