Inherited metabolic disorder cirrhosis

Because hepatitis is not treated in time, it will gradually lead to cirrhosis. When liver diseases such as fatty liver and hepatitis turn into cirrhosis, the harm is quite great. At this time, patients need to pay attention and first check whether there are metabolic diseases or genetic factors, because hereditary metabolic disorders can cause cirrhosis indirectly.

Introduction

Inherited metabolic disorder cirrhosis

cirrhosis in genetic disorders

Cirrhosis caused by various inherited metabolic disorders. Such as glycogen storage disease, galactosemia, hereditary tyrosinemia, hereditary fructose intolerance, α1 antitrypsin deficiency, thalassemia, iron transfer protein deficiency, pyridoxine-dependent anemia, Wilson's disease, hemochromatosis, beta-lipoprotein deficiency, etc. This type of cirrhosis often occurs in children, and may cause liver enlargement, other organs are often affected, and liver failure occurs early.

Metabolic Cirrhosis - Overview

Metabolic cirrhosis is caused by genetic and metabolic diseases that lead to the deposition of certain substances in the liver due to metabolic disorders. It causes Alzheimer's cell degeneration and necrosis, connective tissue hyperplasia and forms cirrhosis. The important ones are: a. Iron metabolism disorders: seen in hemochromatosis. b. Copper metabolism disorder: seen in Wilson's disease. c.a1-Antitrypsin deficiency. d. Typely ghycogensis. e. Galactosemia. f. Tyrosine metabolism disorder (Tyrosinosis), etc.

Metabolic Cirrhosis - Symptoms / Metabolic Cirrhosis

Symptoms of metabolic cirrhosis

Galactosemia

This is a disease of infants, young children and adolescents. It is mainly due to the lack of galactose-1-phosphate-uridyl transferase required for galactose metabolism in hepatocytes and red blood cells, resulting in the accumulation of large amounts of galactose-1-phosphate and galactose in hepatocytes, causing liver damage and possibly leading to cirrhosis. Clinical manifestations of cirrhosis include vomiting, diarrhea, malnutrition, jaundice, ascites, cataracts, mental retardation, galactosemia, galactosuria, and aminoaciduria.

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