What is the normal value of cardiac troponin?

Cardiac troponin is a marker for diagnosing myocardial damage and necrosis. Under normal circumstances, the normal value is less than 0.1μg/L. If it is greater than 0.2, it is the critical point for diagnosing the disease. If it reaches above 0.5, it will be diagnosed as acute myocardial infarction. It may also be the acute stage of viral myocarditis. In this case, treatment must be received as soon as possible, otherwise it will affect physical and mental health, and may even cause sudden death.

1. Significance of cardiac troponin

Troponin is a marker of myocardial injury and necrosis and has important clinical significance for the diagnosis and risk stratification of acute myocardial infarction. Elevated troponin values ​​indicate muscle damage, which can be seen in acute myocardial infarction, unstable angina, pulmonary infarction, heart failure and other diseases that cause myocardial damage, such as pancreatitis and connective tissue diseases. The higher the value, the wider the range of damage. In patients with acute myocardial infarction, it begins to be released within 3 to 6 hours, reaches a peak within 10 to 24 hours, and the time to return to normal is 10 to 15 days and 5 to 7 days for cTnT and cTnI, respectively; elevated levels may also occur in some patients with renal insufficiency.

Elevated troponin combined with evidence of ischemia is helpful for the early diagnosis and treatment of type Ⅰ myocardial infarction; understanding the changing pattern of elevated troponin is helpful for the differential diagnosis of elevated troponin. In case of transient myocardial damage caused by strenuous exercise, tachycardia, acute pulmonary embolism, etc., cTn may increase transiently and return to normal within 1 to 2 days; the increase in cTn caused by heart failure is chronic. These characteristics are helpful in distinguishing it from myocardial infarction.

2. Cardiac troponin reference range

cTnTL is normal; >0.2μg/L is the diagnostic critical value; >0.5μg/L can be diagnosed as acute myocardial infarction; cTnIL is normal; >1.5μg/L is the diagnostic critical value.

III. Hazards of elevated cardiac troponin

The normal value of troponin is less than 0.1 μg/L. Troponin is a specific marker for myocardial necrosis. If troponin levels are elevated, it indicates myocardial cell necrosis. Troponin has a very high specificity and a good sensitivity, so when it is used for measurement, if it is elevated, myocardial cell necrosis should be considered. Generally speaking, when troponin levels are elevated, the following diseases should be considered: 1. Acute myocardial infarction. Generally speaking, troponin levels will increase 4-6 hours after an acute myocardial infarction occurs. Blood tests can detect the increase in troponin levels. Combined with the patient's symptoms and electrocardiogram, myocardial infarction can be confirmed. 2. Acute phase of viral myocarditis. The virus invades myocardial cells, causing myocardial cell necrosis and elevated troponin levels.