Carbohydrate antigens—the key to diagnosing pancreatic cancer

With the development of monoclonal technology, carbohydrate antigens have made rapid progress. At present, many tumors related to pancreatic cancer have been found. Carbohydrate antigens play an important role in the screening of pancreatic cancer, the monitoring of postoperative recurrence and metastasis, and the differentiation of benign and malignant pancreatic tumors. If two or more tumor markers are used for examination, the positive rate can be increased. There are mainly the following types of carbohydrate antigens:

1. Carbohydrate antigen CA19-9 is a pancreatic cancer-related antigen. The sensitivity, specificity and accuracy of carbohydrate antigen CA19-9 in diagnosing pancreatic cancer are 83.1%, 73% and 75% respectively. The level of carbohydrate antigen CA19-9 is not high in patients with small pancreatic cancer, while the level of carbohydrate antigen CA19-9 is higher in patients with larger tumors. It can also be used to judge the prognosis. If the tumor recurs, metastasizes or the condition worsens, carbohydrate antigen CA19-9 will increase significantly again. Therefore, CA19-9 is an effective marker for pancreatic cancer.

2. Carbohydrate antigen CA50 is also an antigen of the Lewis system and has a good correlation with carbohydrate antigen CA19-9. It is not necessary to measure these two antigens at the same time. However, combined detection can improve the sensitivity of pancreatic cancer diagnosis.

3. Span-1: in patients with adenocarcinoma, the level can be as high as 1446 KU/L. This carbohydrate antigen has a sensitivity of 81% and a specificity of 68%, but it is not ideal for the diagnosis of small pancreatic cancer.

4. Dupan-2 has a sensitivity of 50% to 70% for pancreatic cancer. Combined detection with carbohydrate antigen CA19-9 can increase the positive rate to 95%.

The above is the diagnosis of pancreatic cancer. Clinically, it is necessary to choose the appropriate diagnostic method according to the different conditions of the patients. Early exclusion and diagnosis of pancreatic cancer is also of great significance for later treatment. Expert Tips: If your physical health has symptoms of disease, you can choose the appropriate treatment according to your symptoms, but do not delay diagnosis, and do not let your life be ruined in hesitation. You should go to a regular hospital for medical treatment in time to avoid delaying the disease and causing serious consequences. If you have other questions, please consult our online experts or call for consultation. Believe in miracles, I wish you health, happiness, and joy!

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