Analysis of the causes of six major types of malignant melanoma

The cause of malignant melanoma is still unclear, but experts have found that there are six main factors related to the formation of malignant melanoma. Today, experts will analyze these six causes of malignant melanoma in detail.

The causes of malignant melanoma are still very complicated. The main causes of malignant melanoma are:

1. Malignant transformation of existing pigmented moles 60% of malignant melanomas are caused by benign moles. The malignant transformation rate of congenital giant moles is as high as 10% to 30%. Some people believe that the risk of malignant transformation is three times higher for those with more than 20 skin moles. It is well known that the junctional components of junctional moles and mixed moles can be malignantly transformed into melanomas.

2. Endocrine factors: It has long been believed that pregnancy can stimulate the malignant transformation of moles, or exacerbate existing moles, leading to a poor prognosis. There is no definite conclusion on the relationship between the increase of estrogen and the occurrence of moles. The presence of estrogen receptors in melanoma cells indicates that it has a certain relationship with the pathology of moles.

3. Sunlight and ultraviolet radiation factors. Ultraviolet radiation is the main factor causing melanin. Ultraviolet rays are very sensitive to DNA damage and can lead to a decrease in systemic immunity. Many data support the pathogenic effects of sunlight and ultraviolet rays.

4. Racial genetic factors: The incidence of melanoma in white Americans is higher than that in blacks, and that in Japanese is lower than that in whites, while that in Australians, especially the Celts from the UK, is the highest. Among human patients with melanoma, 1% to 6% have a family history, and the proportion of multiple melanoma with a family history can be as high as 44%, which is an autosomal dominant inheritance, and is the cause of malignant melanoma that we recognize.

5. Trauma and chronic irritation factors Trauma and chronic irritation factors are one of the causes of malignant transformation of pigmented skin lesions. For example, the relationship between the occurrence of scar cancer and chronic irritation and trauma has long been known. There are also reports of cases where benign moles were treated with incomplete irritation methods such as corrosion and electric cauterization, which caused sudden spread and death. As for the relationship between trauma and the occurrence of malignant melanoma, it is difficult to be completely sure.

6. Immune factors are also one of the causes of malignant melanoma. Circulating antibodies to tumor cell antigens have been detected in patients with malignant melanoma. Among patients with malignant melanoma, cytoplasmic antibodies have cross-reactions, while anti-membrane antibodies have stronger specificity. Antibodies bind to melanoma cells in the body. When the tumor is localized, the antibody level is the highest. Before metastasis occurs, the antibody level decreases significantly or disappears.

The above is the introduction of "The Causes of Malignant Melanoma" for reference only. There are many causes of malignant melanoma. We should learn to avoid these risk factors to prevent the deterioration of malignant melanoma and affect your life. If you have other questions about the causes of malignant melanoma, please consult our online experts for more information.

For more information, please visit the melanoma special topic at http://www..com.cn/waike/hssl/ or consult an expert for free. The expert will then give a detailed answer based on the patient's specific situation.