What causes pituitary tumors

We cannot take pituitary tumors lightly. Its harm is very serious. We cannot ignore its treatment just because it is a benign tumor. It can cause a variety of complications and seriously affect the patient's work and life. Everyone is also very concerned about the cause of pituitary tumors. Let's listen to the experts' introduction.

Causes of pituitary tumors:

1. Genetics such as multiple endocrine neoplasia-1MEN1, excessive PROP-1, and transcription factor defects;

2. Hypothalamic lesions such as excess GHRH or CRH, dopamine deficiency, and possible receptor activation;

3. Somatic signal transduction mutations such as abnormal growth factor and cytokine action;

4. Gene activation or disruption of cell cycle regulation;

5. Oncogene loss, oncogene GSP, RAS mutation, PTTG-1;

6. Environmental factors, radiation effects, and estrogen use;

7. The structures surrounding the tumor are damaged. As the tumor grows, it invades and compresses important surrounding structures, such as the optic nerve, cavernous sinus, basilar cerebral artery, hypothalamus, third ventricle, brain stem, etc., leading to corresponding functional disorders, manifested as decreased vision, visual field defects, hemiplegia, fixed eyeballs, diplopia, intellectual and memory disorders, mental changes, headaches, hydrocephalus, etc.

8. Endocrine disorders. Pituitary tumors with secretory functions secrete hyperhormones, causing an increase in the patient's PRL, GH, ACTH, TSH and other hormones, thereby causing menstrual disorders, lactation, miscarriage, infertility, sexual dysfunction, obesity, ugly face, gigantism, enlarged hands and feet, increased hair, rough skin, etc.; those with hypopituitarism will show symptoms of fatigue, fear of cold, etc.

9. Metabolic disorders, decreased blood potassium, sodium, chloride, and calcium, weakness, vomiting, nausea, diarrhea, abdominal distension, spontaneous fractures of multiple ribs and vertebrae. Low immune function: easy to catch a cold, easy to get cancer. Psychological pressure. Pituitary tumors can occur at any age, but they are more common in young and middle-aged people. Because pituitary tumors have serious damage to human growth, development, physical and mental health, fertility, and multi-organ functions, people with pituitary tumors should actively seek early treatment.

Everyone should know the causes of pituitary tumors so that they can prevent themselves from developing the disease and protect their pituitary gland. At the same time, everyone should face the disease actively after suffering from pituitary tumors, take treatment methods, and strive to restore their pituitary gland to health as soon as possible.