What is the effect of erythromycin injection

Erythromycin contains rich active ingredients, so it can play a powerful role in antibacterial and anti-inflammatory effects. The most common forms of erythromycin that we see in daily life should be erythromycin ointment or erythromycin eye ointment. In fact, in some medical fields, erythromycin is also used as an injectable drug injected into the human vein. If erythromycin is used as an injectable drug, what kind of pharmacological effect will it have on the human body?

What is the role of intravenous erythromycin?

Erythromycin is a macrolide antibiotic with an antibacterial spectrum similar to that of penicillin. It has a strong antibacterial effect mainly against Gram-positive bacteria such as Staphylococcus aureus, hemolytic Streptococcus, Pneumococcus, Corynebacterium diphtheriae, Bacillus anthracis and Clostridium difficile. It has a certain effect on Gram-negative bacteria such as meningococci, gonococci, pertussis bacteria, influenza bacteria, Brucella, some Shigella dysenteriae and Escherichia coli. The characteristic is that the strains are resistant to penicillin and sensitive to this product.

The mechanism of action of erythromycin is mainly to bind to the 50S subunit of the ribonucleosome, inhibit peptidyl transferase, affect the translocation process of the ribonucleosome, hinder the growth of peptide chains, and inhibit the synthesis of bacterial proteins. It is an antibacterial agent clinically used mainly for penicillin-resistant Staphylococcus aureus infections and penicillin-allergic Staphylococcus aureus infections. It is also used for respiratory tract infections, Legionella pneumonia, mycoplasma pneumonia, skin and soft tissue infections caused by hemolytic streptococci and pneumococci. In addition, for diphtheria patients, the combination of this product and diphtheria antitoxin has significant therapeutic effect.

In addition, erythromycin is destroyed and reduced in efficacy in acidic infusions and should generally not be used in combination with low pH glucose infusions. In 500ml of 5% to 10% glucose infusion, add 0.5ml of vitamin C injection or 5% sodium bicarbonate injection to raise the pH to above 5, and then add erythromycin lactobionate to help stabilize it.

Finally, a friendly reminder: some patients may occasionally experience venous irritation or phlebitis after intravenous administration. Therefore, patients should use erythromycin under the guidance of a doctor.