Why do we need albumin for ascites? What are the components?

Many patients with liver diseases, especially cirrhosis, should have used the drug albumin. Albumin drugs can effectively help patients with liver disease alleviate and adjust the problem of ascites. The active ingredients in them also have a certain effect on improving liver disease. When using albumin to treat ascites, patients must follow the doctor's instructions and not take it at will.

Human albumin pharmacology: Human albumin drug therapy is classified into plasma substitutes and plasma protein components. ATC classification code: B05AA01. The amount of human albumin in plasma exceeds half of the total plasma protein and accounts for 10% of liver protein synthesis. Physical and chemical data: 5% human albumin has a slight hypocolloidal effect on normal plasma. 20% human albumin has a relatively high colloid pressure effect. The important physiological function of albumin is to maintain blood colloid osmotic pressure and its transport function. Albumin maintains a stable circulating blood volume and acts as a carrier for hormones, enzymes, drugs, and toxins. Human albumin is a normal component of human plasma and its function is the same as physiological albumin. In animal experiments, single-dose toxicity testing is meaningless and inadequate for evaluating toxicity, lethal doses, or dose-effect relationships. Repeated-dose toxicity studies are not feasible due to the development of antibodies to the heterologous protein in animal models. To date, human albumin has not been reported to be associated with embryotoxicity, carcinogenicity, and potential mutagenicity. No signs of acute toxicity were found in animal models. You can also log in to Cardinal Health Pharmacy to learn about the medication for cirrhosis. It is recommended to consult professionals when using human albumin drugs!

What are the components of human serum albumin used to treat ascites?

The components of human albumin are human albumin (g/100ml): 20N-acetyltryptophan sodium: 16mmol/LSodium zincate: 16mmol/LSodium chloride: 140mmol/LWater for injection: add to volume. The upper limit of aluminum content in human albumin according to the European Pharmacopoeia is not more than 200μg/L.

The incidence of ascites due to cirrhosis is still on the rise, and the number of patients admitted to the hospital due to ascites due to cirrhosis is also increasing year by year.