What is the cause of cutaneous amyloidosis

Cutaneous amyloidosis is actually a disease caused by the deposition of amyloid substances in tissues or organs. If it is not effectively treated, it may lead to chronic inflammatory diseases such as common rheumatoid arthritis, tuberculosis, etc., so it is necessary to understand the pathological scientific treatment.

1. Cutaneous amyloidosis: Amyloidosis refers to a disease caused by the deposition of amyloid substances in tissues or organs. Uniform and unstructured amyloid deposits in tissues or organs, causing varying degrees of functional disorders in the deposited tissues and organs. Amyloid protein is a complex of globulin and mucopolysaccharide. It is named because its chemical reactions are similar to starch (such as reaction with iodine), but it actually has nothing to do with starch. This disease is generally divided into primary and secondary. In the former, amyloid protein is mainly deposited in the interstitial tissue and can be divided into localized and systemic. The latter is often secondary to chronic inflammatory diseases such as tuberculosis, rheumatoid arthritis, osteomyelitis, etc.

2. Amyloidosis refers to a disease caused by the deposition of amyloid substances in tissues or organs, and actually has nothing to do with starch. It is generally believed that this disease is autosomal dominant or related to metabolic disorders. Depending on the organs involved, it is divided into systemic or cutaneous amyloidosis, and these two types are divided into primary and secondary.

3. Depending on the different skin lesions, cutaneous amyloidosis can be divided into: lichenoid amyloidosis, plaque amyloidosis, mixed amyloidosis, nodular amyloidosis, and poikiloderma amyloidosis, etc.

4. Lichen amyloidosis is the most common, with no age limit for onset. Typical skin lesions are papules occurring on the anterior tibia of the lower leg, ranging in color from normal to yellowish-brown, about 1 to 3 mm in size, with a few scales on the surface and often excessive keratinization and roughness on the top; the papules are densely packed into patches, but often do not fuse, and are severely itchy. Sometimes the papules are arranged in a rosary-like pattern along the skin texture, which is quite characteristic. They may also merge into plaques with a wart-like surface, similar to hypertrophic lichen planus or chronic simple lichen planus, but the papules on the surface of the plaques can still be identified, and brown papules can also be seen on the edges of the plaques. Over time, the skin lesions may gradually extend to the flexor side of the calf, thigh, ankle and dorsum of the foot, and occasionally to the extensor side of the forearm, abdomen or chest wall.