How to read the instructions for ceftriaxone?

Ceftriaxone is a relatively commonly used prescription drug. It is used to treat various infectious diseases. It has a particularly strong efficacy and the ability to kill viruses. Therefore, it is widely used in various disease events. Although ceftriaxone is effective, not many people know about it. Let’s take a look at how to read the instructions for ceftriaxone. I hope everyone can learn more about this strange prescription drug.

Indications

Used for lower respiratory tract infections, urinary tract infections, biliary tract infections, abdominal infections, pelvic infections, skin and soft tissue infections, bone and joint infections, sepsis, meningitis, etc. caused by sensitive pathogens, as well as prevention of surgical infections. A single dose of this product can treat simple gonorrhea.

Dosage

Administer by intramuscular injection or intravenous drip.

(1) Preparation of intramuscular injection solution: Add 3.6 ml of sterile water for injection, sodium chloride injection, 5% glucose injection or 1% lidocaine hydrochloride to 1 g bottle to make a solution containing 250 mg of ceftriaxone per 1 ml.

(2) Preparation of intravenous solution: Add 9.6 ml of the above diluent (except lidocaine) to the 1 g bottle to make a solution containing 100 mg of ceftriaxone per 1 ml. Dilute with 100-250 ml of 5% glucose injection or sodium chloride injection and drip intravenously.

The usual dose for adults is 1-2 g per 24 hours or 0.5-1 g per 12 hours by intramuscular or intravenous drip. The maximum dose is 4g per day. The course of treatment is 7 to 14 days.

The usual dose for children is intravenous drip, 20 to 80 mg/kg per day based on body weight. Children over 12 years old should use the adult dose.

The recommended dose for the treatment of gonorrhea is a single intramuscular injection of 0.25 g.

Adverse Reactions

Adverse reactions are related to the dosage and course of treatment. Local reactions include phlebitis (1.86%), in addition there may be allergic reactions such as rash, dermatitis, itching, urticaria, edema, fever, bronchospasm and serum sickness (2.77%), headache or dizziness (0.27%), soft stools, diarrhea, nausea, vomiting, stomatitis, abdominal pain, colitis, jaundice, flatulence, taste disorders and indigestion and other gastrointestinal reactions (3.45%). Laboratory abnormalities were found in approximately 19% of cases, of which 14% were hematological abnormalities, including eosinophilia, bleeding, thrombocytopenia or thrombocytopenia, and leukopenia. The rates of liver and kidney dysfunction were 5% and 1.4% respectively. Other rare side effects include increased liver enzymes and oliguria.