Serum myoglobin

Serum myoglobin is an important substance in the human body, mainly existing in muscles, and has a relatively important impact on various functions of the human body. However, if serum myoglobin is abnormal, it means that the human body has some adverse symptoms, especially acute myocardial infarction, the probability of which is the highest. Acute myocardial infarction is a relatively serious disease, so we need to pay special attention to serum myoglobin values.

Introduction

Serum myoglobin (Mb) is one of the earliest markers to increase in patients with acute myocardial infarction (AMI). The blood concentration can increase within 2-4 hours, and Mb is elevated in almost all AMI patients within 6-10 hours. Therefore, Mb positivity is particularly helpful in the diagnosis of early AMI. The condition can return to normal within 24 hours of onset, so Mb negativity is particularly helpful in excluding the possibility of infarction expansion during the course of AMI. The immunoturbidimetric method can complete the determination within 10 minutes.

Normal value

(1) ELISA method: 3.5-22.8 ng/ml. (2) RIA method: Serum of healthy adults: 29±16.3μg/L.

Clinical significance

(1) The measurement of serum Mb is a sensitive indicator for the early diagnosis of acute myocardial infarction. When blood is drawn 12 hours after the onset of chest pain, serum Mb will be elevated, while CK and AST are normal. The disease peaks within 24 hours. (2) Elevated serum Mb levels in patients undergoing cardiac surgery can be used as an important objective indicator for determining the extent of myocardial injury and healing. (3) Clinical myopathy studies have found that serum Mb levels in patients with pseudohypertrophic muscular dystrophy are elevated, reaching as high as 1150 μg/L. (4) Acute or chronic renal insufficiency, severe congestive heart failure, etc. also increase.

Precautions

Strenuous exercise, intramuscular injection, muscle trauma, cardiac catheterization, etc. It can also increase myoglobin.

Related diseases

Glycogen storage disease type V, glycogen storage disease type V in children, muscular dystrophy, viral myocarditis, polymyositis-dermatomyositis, polymyositis, progressive muscular dystrophy.

Related symptoms

Non-pitting edema of the limbs, severe pseudohypertrophic dystrophy.