Probability of inheritance of muscular dystrophy

It is well known that humans have many genetic diseases, and many of them still have no complete way to overcome them. That is why screening should be done before pregnancy for the sake of eugenics. Muscular dystrophy is also a hereditary disease. It is a common muscle disease. The inheritance rate of this disease is not high, but it still needs to be given enough attention. So how likely is it to inherit muscular dystrophy?

Muscular dystrophy is also one of the common muscle diseases, also known as progressive muscular dystrophy, which is a group of genetic diseases that originate in the muscles.

The main clinical manifestations are skeletal muscle weakness and atrophy, which often begin at the proximal end of the muscle and show bilateral symmetry and muscle weakness and atrophy.

Pseudohypertrophy is the most common clinical muscular dystrophy and poses the most serious health hazards. It is inherited in a sex-linked recessive manner, so it mainly affects males. Women who are only carriers of abnormal chromosomes usually do not develop the disease, that is, all men are sick and women are carriers. Occasionally, there are female cases, which are mainly divided into:

① Duchenne type: usually onset in early childhood, characterized by delayed walking age, slow walking, dislike of running, and easy stumbling. It is difficult to get up after falling and it is difficult to go up stairs. Clinical examinations show that most patients had their feet very wide apart when they were children, and their spines were lordotic. Gradual atrophy and weakness of the scapular muscles appeared, with the arms unable to be raised high and the shoulder blades protruding in a wing-like shape, which is called winged scapula. Duchenne muscular dystrophy has a poor prognosis. Generally, children lose the ability to walk around the age of 10, develop spinal and limb deformities, and in the late stages, their limbs become contracted and they become completely unable to move. IQ often declines to varying degrees. More than half of the children also suffered varying degrees of myocardial damage.

②Bocker type: It is a hereditary disease like Duchenne type. It is also sex-linked and stably inherited. Becker's type is milder than Duchenne's type. It usually occurs in adolescents around the age of 15. Pseudohypertrophy of the calf gastrocnemius muscle is very prominent. The disease progresses slowly and the patient can maintain the working capacity into middle age. Most patients can give birth and the boys born are not affected, while the girls born may become gene carriers.