Does glucose plus saline have an anti-inflammatory effect?

Glucose actually has many applications in life. For some patients, glucose needs to be used according to their own situation. But some friends would ask the editor: Does glucose plus saline have an anti-inflammatory effect? Actually, no. If you want to reduce inflammation, you can actually choose some anti-inflammatory drugs. If you don’t know what to choose, you can actually consult a doctor.

Glucose solution has different concentrations for different uses:

(1) When patients have reduced or no food intake due to some reasons, they can generally be given 25% glucose injection intravenously and replenish body fluids at the same time. The amount of glucose is calculated based on the required heat energy.

(2) Glucose is the most important energy supply substance in total intravenous nutrition therapy. In non-protein heat energy, the ratio of heat provided by glucose and fat is 2:1. The specific amount depends on clinical heat needs. Depending on the amount of fluid replacement required, glucose can be prepared into different concentrations of 25% to 50%. Insulin can be added if necessary, with 1 unit of regular insulin added for every 5 to 10 grams of glucose. Since normal use of hypertonic glucose solution is highly irritating to veins and requires infusion of fat emulsion, large intravenous drip is generally used.

(3) For severe hypoglycemia, 20-40 ml of 50% glucose injection can be given as an intravenous push.

(4) Starvation ketosis: For severe cases, 5% to 25% glucose injection can be given by intravenous drip. 100g of glucose per day can basically control the condition.

(5) Dehydration: For isotonic dehydration, give 5% glucose injection by intravenous drip.

(6) For hyperkalemia, use 10% to 25% injection solution, with 1 unit of regular insulin added for every 2 to 4 g of glucose infusion, which can reduce serum potassium concentration. However, this therapy only allows extracellular potassium ions to enter cells, and the total potassium content in the body remains unchanged. If potassium removal measures are not taken, hyperkalemia may still occur again.

(7) Rapid intravenous injection of 20 to 50 ml of hypertonic solution for tissue dehydration (generally 50% glucose injection) But the effect is short-lived. In clinical practice, attention should be paid to preventing hyperglycemia and it is currently used less frequently. When used to regulate the osmotic pressure of peritoneal dialysis fluid, 20 ml of 50% glucose injection, i.e. 10 g of glucose, can increase the osmotic pressure of 1 L of peritoneal dialysis fluid by 55 mOsm/kg H2O.

Normal saline is a 0.9% sodium chloride aqueous solution. Because its osmotic pressure value is roughly the same as that of normal human plasma and tissue fluid, it can be used for fluid replacement (without reducing or increasing the sodium ion concentration in the normal human body) and other medical purposes. It is also often used for in vitro culture of living tissues and cells. It is the concentration of the liquid environment in which human cells are located.