Will anti-inflammatory drugs cause hematuria?

During the treatment of some diseases, certain factors may cause the occurrence of another disease. I believe most people are aware of this situation. Some people have experienced hematuria after taking anti-inflammatory drugs. Because many people are not sure whether this situation is true, most people are skeptical. So, can anti-inflammatory drugs cause hematuria?

First, will anti-inflammatory drugs cause hematuria? Red urine usually turns red because there are red blood cells in the urine, which is medically called hematuria. The causes of hematuria are very complicated. There are hundreds of diseases that can cause hematuria, and it is not easy to diagnose correctly. If hematuria is accompanied by nose bleeding, bleeding gums, or skin bleeding, it may be due to a systemic bleeding disease, such as thrombocytopenia, allergic purpura, hemophilia, or even leukemia. Hematuria is just a manifestation of systemic bleeding. If hematuria is accompanied by fever, joint swelling and pain, skin lesions, and multiple organ damage, it may be a connective tissue disease (such as systemic lupus erythematosus, nodular arteritis, etc.). If hematuria is accompanied by hypertension, edema, and proteinuria, it is mostly glomerulonephritis. If hematuria is accompanied by dull pain in the waist and abdomen, urgency, frequency, and pain when urinating, it is mostly a urinary tract infection or tuberculosis. If hematuria is accompanied by distension and pain in the lower back or abdominal cramps on one side, kidney or ureteral stones are most likely the cause, especially if the patient is in so much pain that he cannot move comfortably in bed, the cause is most likely ureteral stones. If hematuria is accompanied by difficulty, strain, and dripping of urine, in elderly men, it is mostly due to prostate hypertrophy, while in middle-aged men, urethral stenosis, urethral stones, or bladder tumors should be considered.

Second, drugs that cause red urine include: rhubarb, rifampicin, phenolphthalein, phenytoin sodium, deferoxamine, danthraquinone; cyclophosphamide, doxorubicin, warfarin, mitotane, phenazopyridine, chloroquine, quinine, levodopa, methyldopa, various herbs containing aristolochic acid, metronidazole, furantoin, chlorpromazine, sulfonamides, etc.

Will anti-inflammatory drugs cause hematuria? Since renal bleeding is first discharged through the ureter, long blood clots are often formed when passing through the ureter; if there is bleeding due to lesions in the bladder, the blood clots will be larger and irregular. The interval between bleeding episodes of bladder tumor is shorter than that of kidney tumor, and the frequency of urination is slightly higher than normal. It is generally acknowledged by scholars at home and abroad that the incidence of bladder cancer is very high among heavy smokers, and we should be especially vigilant about painless hematuria in these elderly people. After men are over 50 years old, the prostate will undergo varying degrees of hyperplasia, which affects the smooth flow of urine and leads to secondary infection and congestion of the bladder mucosa and prostate. It may also cause venous rupture and painless hematuria, which should be distinguished from bladder tumors. Another common disease causing painless hematuria in elderly women is urethritis. Its characteristics are: less blood in the urine, and often accompanied by fresh blood stains on toilet paper; long-term history of chronic urethritis; poor urination, bifurcated urine stream, urethral burning discomfort; doctors can see purple-red granulation-like hyperplastic tissue located inside the external urethral opening with the naked eye, which is mostly spherical or hemispherical. This disease is a benign lesion and can be cured by electrosurgical resection, urethral dilation and anti-inflammatory treatment. In addition, diseases such as Henoch-Schonlein purpura, hemorrhagic fever, and lesions of organs adjacent to the urinary system, such as the appendix, rectum, colon, uterus, and ovaries, can also cause hematuria.