What are the causes of pancreatic cancer?

Many people are addicted to smoking and drinking, but they are often the cause of your illness. It is generally believed that the onset of pancreatic cancer is closely related to diet, emotions, and environmental carcinogens. For example, smoking and drinking are considered to be factors that induce pancreatic cancer. Emotional frustration and internal injuries can lead to dysfunction of the qi and blood of the internal organs, which can also induce tumors. In addition, people who live in an environment polluted by carcinogens for a long time have a significantly increased incidence of tumors. So what are the causes of pancreatic cancer?

Drinking: The incidence of pancreatic cancer varies among different races. According to Silverman et al., a study on the relationship between drinking and the incidence of pancreatic cancer in black and white Americans showed that black male heavy drinkers and female moderate drinkers had a higher incidence rate than white people.

Smoking: A large number of studies support the close connection between pancreatic cancer and smoking. Possible mechanisms of smoking causing pancreatic cancer: ① Smoking promotes the secretion of tobacco-specific N-nitrite, a carcinogen, into the bile duct, which then flows back into the pancreatic duct; ② The specific effects of tobacco-specific N-nitrite on organs can flow into the pancreas with the blood; ③ Smoking increases blood lipid levels and promotes pancreatic cancer. Smokers may be prone to cancer due to low cell methylation levels. Experiments by Stolzenberg et al. have confirmed that maintaining adequate folic acid and pyridoxal concentrations can reduce the risk of pancreatic cancer associated with smoking.

Coffee: Surveys have found that coffee can increase the risk of pancreatic cancer by four times. Studies have shown that coffee can inhibit DNA repair and induce mitosis before DNA replication is completed, which is the main cause of cancer.

Diabetes: Experimental studies have shown that insulin can promote the growth of pancreatic cancer cells in vitro or in vivo; high concentrations of insulin can activate the insulin-like growth factor-1 receptor, producing a growth-promoting effect including changes in cell cycle progression.

Chronic pancreatitis: Most epidemiological and molecular epidemiological studies support that chronic pancreatitis can develop into pancreatic cancer. Friess's study showed that among 5,600 genes, 34 genes were expressed less in patients with pancreatic cancer and chronic pancreatitis, 157 genes were expressed more strongly in chronic pancreatitis, and 152 of them were also expressed more strongly in pancreatic cancer. This study proved at the molecular level that there may be some connection between chronic pancreatitis and pancreatic cancer.

The above are the causes of pancreatic cancer. Please pay attention to your diet and daily life. If you already have this disease, please go to the hospital as soon as possible. We will arrange a suitable treatment plan for you. If you have any questions, you can contact our online experts. They will give you detailed answers. I hope that patients can cherish their bodies. Your health is the happiness of your family. I wish you health and happiness!

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