Medication guidance for gastroparesis syndrome caused by gastric cancer surgery

Gastroparesis is a common complication after gastric cancer surgery, which is often related to factors such as vagus nerve resection during surgery. Gastroparesis can affect the patient's diet and rest, which is not conducive to the patient's recovery. Patients with severe gastroparesis can take drug treatment as prescribed by the doctor.

Piperidine benzamide derivatives

Cisapride, a representative drug of this class of drugs, can promote the release of postganglionic acetylcholine in the intestinal myometrial plexus, improve the contractility of gastrointestinal smooth muscle, and promote gastric motility. Cisapride also has an antiemetic effect, and since it has no dopamine receptor blocking effect, it has no adverse reactions to the central nervous system. It should be noted that patients with heart disease should avoid using it.

Macrolide antibiotics

Commonly used erythromycin is a gastrointestinal motility receptor agonist that can enhance the motility of the gastric antrum and small intestine, and is suitable for gastroparesis caused by various reasons. Postoperative intravenous drip of low-dose erythromycin has a significant promoting effect on gastrointestinal motility after abdominal surgery. Long-term use can induce rapid tolerance reaction, so it can be used in combination with other drugs for treatment. Common adverse reactions include abdominal cramps and vomiting.

Tegaserod, a 5-HT receptor agonist

This drug can enhance gastric emptying function, but there are safety issues in the treatment of diabetic gastroparesis. Adverse reactions include abdominal pain, diarrhea, dizziness, and back pain.