Are genetic factors the main cause of esophageal cancer?

It can be seen from most cancers that cancer is closely related to heredity. Cancer is the result of various environmental factors acting on individuals with different genetic qualities over a long period of time. The family history of cancer in esophageal cancer patients is also higher than that of ordinary residents. Is there a genetic tendency for esophageal cancer? Is hereditary factor the main cause of esophageal cancer? Let's take a look at the research results.

With the continuous advancement of science and technology, molecular biology and molecular genetics are constantly developing. Oncologists have shown through numerous evidences that the malignant transformation of normal cells involves changes in the structure and regulation of genetic material. What is inherited from the previous generation is not the tumor itself, but the susceptibility to tumors. The essence of this tumor susceptibility may be caused by abnormal DNA structure or replication, transcription, and expression errors in the patient's body, or it may be related to the activation of carcinogens, the weakening or loss of enzyme activity required for harmlessness, or it may be the result of congenital or acquired chromosomal aberrations or certain immune genetic defects. It has been observed that the chromosomal aberration rate of high-incidence family members is significantly higher than that of the control group. Experiments have shown that lymphocytes of high-incidence family members are more prone to sister chromosome exchange (SCE), and possible unique fragile sites have been found on their chromosomes, such as 1p13-p36 and 4q21-q31, etc. These sites may play some important synergistic roles in the occurrence of esophageal cancer.

Genetic factors play an inevitable role in esophageal cancer, usually inherited from parents, which increases the risk of developing the disease. If you are born in a family with the disease, you should pay more attention to and avoid esophageal cancer to make up for your congenital deficiencies and defects.