Causes of bone metastasis of lung cancer

Lung cancer care is also very important for patients. If the care is improper, it will not only affect the health recovery of lung cancer patients, but also may cause cancer cells to spread and metastasize. Lung cancer metastasis can be divided into multiple parts, among which the most common is lung cancer bone metastasis. In view of this phenomenon, only by understanding the causes and symptoms of lung cancer bone metastasis as early as possible can we help patients get rid of it as soon as possible. Let's learn more about it together:

Bone is a common site for lung cancer metastasis. The incidence of lung cancer bone metastasis is related to the site and pathological type of the primary cancer. Adenocarcinoma has the highest incidence of bone metastasis, followed by small cell lung cancer and squamous cell carcinoma. The lesions of bone metastasis are mainly multiple. The common sites are: ribs, thoracic vertebrae, lumbar vertebrae, and pelvis; adenocarcinoma mainly metastasizes to the chest and pelvis. Adenocarcinoma is the main bone metastasis of lung cancer, and it often invades the ribs and thoracic vertebrae.

Causes of lung cancer bone metastasis

Lung cancer bone metastasis may occur in the periphery of the lungs, which is likely to cause direct invasion and involve the ribs and thoracic vertebrae. In addition, tumor cells reach the bones through the blood circulation and tend to grow and multiply in the trunk bones containing red bone marrow, but rarely in the long bones of the limbs containing yellow bone marrow.

Bone metastasis of lung cancer is mostly osteolytic destruction, while small cell undifferentiated carcinoma and a few adenocarcinomas may show osteoblastic destruction. Hypercalcemia in cancer patients is not mainly caused by increased osteoclast activity caused by bone metastasis, which causes calcium in the bones to enter the extracellular fluid. It may be caused by PTHrP secreted by the tumor and has nothing to do with bone metastasis. Therefore, the incidence of hypercalcemia is not high in lung cancer patients with bone metastasis.