The harm of bladder cancer to the body

Bladder cancer is a malignant tumor in the bladder. Bladder cancer usually originates from the transitional cells of the bladder (bladder cell lines). It is caused by environmental influences and external risk factors, but it is also related to the patient's genetic basis. Among urinary tumors in my country, it ranks first in both incidence and mortality, and the incidence has been increasing in recent years.

Causes and risk factors of bladder cancer ① Workers who are exposed to aromatic substances for a long time, such as dyes, leather, rubber, painters, etc., may have a high incidence of bladder tumors.
② Smoking is also a factor that increases the incidence of bladder tumors. Recent studies have shown that smokers increase the metabolism of the carcinogenic substance tryptophan in their urine by 50%. When smoking stops, tryptophan levels return to normal.
③ Abnormal tryptophan metabolism in the body. Abnormal tryptophan metabolism can produce some metabolites, such as 3-hydroxy-2-aminoacetophenone and 3-hydroxy-o-aminobenzoic acid, which can directly affect the synthesis of RNA and DNA in cells. These metabolites are excreted into the bladder through the action of the liver and have carcinogenic effects after being acted on by β-glucuronidase.
④ Long-term local irritation of the bladder mucosa. Long-term local irritation of the bladder wall, such as long-term chronic infection, long-term irritation of bladder stones and urinary tract obstruction, may be factors that induce cancer. Glandular cystitis and mucosal leukoplakia are considered to be precancerous lesions that can induce cancer.
⑤ Drugs. Taking large amounts of phenacetin has been proven to cause bladder cancer.